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Details on Person Stalling of DNA replication fork and RPA binding

Class:Id	Reaction:176175
_displayName	Stalling of DNA replication fork and RPA binding
_doRelease	TRUE
_timestamp	2016-11-10 00:56:12
authored	[InstanceEdit:176227] Borowiec, JA, 2006-02-25 17:40:15
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08
edited	[InstanceEdit:176160] D'Eustachio, P, 2006-02-25 17:41:28
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
input	[OtherEntity:176104] Persistent single-stranded DNA [nucleoplasm] [Complex:68462] RPA heterotrimer [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:176362] Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand [LiteratureReference:176190] Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint [LiteratureReference:176317] Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage [LiteratureReference:176266] Human replication protein A binds single-stranded DNA in two distinct complexes
modified	[InstanceEdit:177296] D'Eustachio, P, 2006-03-27 18:48:54 [InstanceEdit:1532859] D'Eustachio, P, 2011-08-25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Stalling of DNA replication fork and RPA binding
output	[Complex:176293] RPA complexed to ssDNA [nucleoplasm] [Homo sapiens]
releaseDate	2006-04-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359284] R-HSA-176175.3
summation	[Summation:176300] When a DNA replication fork encounters DNA lesions (e.g., cy...
(hasEvent)	[Pathway:176187] Activation of ATR in response to replication stress [Homo sapiens]
(precedingEvent)	[Reaction:176101] Recruitment of Rad17-RFC complex to DNA [Homo sapiens] [Reaction:176250] Binding of ATR-ATRIP to the RPA-ssDNA complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789415] Update Tracker - [Reaction:176175] Stalling of DNA replication fork and RPA binding - v38:[removeCatalystActivity]
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No pathways have been reviewed or authored by Stalling of DNA replication fork and RPA binding (176175)