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Details on Person The Rad17-RFC complex is a heteropentamer structurally simil...

Class:IdSummation:176173
_displayNameThe Rad17-RFC complex is a heteropentamer structurally simil...
_timestamp2006-03-03 16:44:58
created[InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08
literatureReference[LiteratureReference:176120] Dial 9-1-1 for DNA damage: the Rad9-Hus1-Rad1 (9-1-1) clamp complex
[LiteratureReference:176368] Purification and characterization of human DNA damage checkpoint Rad complexes
[LiteratureReference:176209] Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
[LiteratureReference:176202] The PCNA-RFC families of DNA clamps and clamp loaders
[LiteratureReference:176185] cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster
[LiteratureReference:176152] Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling
[LiteratureReference:176117] Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA
[LiteratureReference:176188] Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination
textThe Rad17-RFC complex is a heteropentamer structurally similar to RFC. The Rad17-RFC complex contains the four smaller RFC subunits (Rfc2 [p37], Rfc3 [p36], Rfc4 [p40], and Rfc5 [p38]) and the 75 kDa Rad17 subunit in place of the Rfc1 [p140] subunit. The Rad17 complex contains a weak ATPase that is poorly stimulated by primed DNA. Along with binding the 9-1-1 complex and RPA, the Rad17-RFC complex interacts with human MCM7 protein. Each of these interactions is critical for Chk1 activation.

The Rad17 subunit is conserved evolutionarily with the protein showing 49% identity at the amino acid level with the S. pombe rad17 protein. Targeted deletion of the N-terminal region of mouse Rad17 leads to embryonic lethality, strongly suggesting that human Rad17 is also essential for long-term viability.

(summation)[Complex:176353] RAD17:RFC [nucleoplasm] [Homo sapiens]
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