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Details on Person Recruitment and activation of Chk1

Class:Id	Reaction:176116
_displayName	Recruitment and activation of Chk1
_doRelease	TRUE
_timestamp	2016-11-10 00:56:36
authored	[InstanceEdit:176227] Borowiec, JA, 2006-02-25 17:40:15
catalystActivity	[CatalystActivity:176203] protein serine/threonine kinase activity of ATR:ATRIP [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:176246] D'Eustachio, P, 2006-03-03 16:44:08
edited	[InstanceEdit:176160] D'Eustachio, P, 2006-02-25 17:41:28
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
input	[SimpleEntity:29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:113826] CHEK1 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:176273] ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 [LiteratureReference:176337] ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage [LiteratureReference:75006] Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.
modified	[InstanceEdit:177296] D'Eustachio, P, 2006-03-27 18:48:54 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment and activation of Chk1
output	[SimpleEntity:113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:113838] p-S317,S345-CHEK1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:176298] Activation of claspin [Homo sapiens] [Reaction:176250] Binding of ATR-ATRIP to the RPA-ssDNA complex [Homo sapiens] [Reaction:176318] Loading of claspin onto DNA during replication origin firing [Homo sapiens] [Reaction:176264] Recruitment of the Rad9-Hus1-Rad1 complex to DNA [Homo sapiens] [Reaction:176101] Recruitment of Rad17-RFC complex to DNA [Homo sapiens]
releaseDate	2005-06-13
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361472] R-HSA-176116.3
summation	[Summation:176165] Chk1 is a checkpoint kinase activated during genotoxic stres...
(hasEvent)	[Pathway:69473] G2/M DNA damage checkpoint [Homo sapiens] [Pathway:176187] Activation of ATR in response to replication stress [Homo sapiens]
(precedingEvent)	[Reaction:69604] Phosphorylation of CDC25A by CHEK1 [Homo sapiens] [Reaction:75010] Phosphorylation of Cdc25C at Ser 216 by Chk1 [Homo sapiens] [Reaction:75028] Phosphorylation of Wee1 kinase by Chk1 [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:9943662] CHEK1 phosphorylates NEK11 [Homo sapiens] [BlackBoxEvent:9943678] CHEK1 phosphorylates CHEK2-phosphorylated CDC25A [Homo sapiens]
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No pathways have been reviewed or authored by Recruitment and activation of Chk1 (176116)