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Details on Person In the Golgi apparatus, TGF-beta-1 (TGFB1) is activated by f...
| Class:Id | Summation:176017 |
|---|---|
| _displayName | In the Golgi apparatus, TGF-beta-1 (TGFB1) is activated by f... |
| _timestamp | 2021-07-19 16:31:54 |
| created | [InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50 |
| literatureReference | [LiteratureReference:174846] Processing of transforming growth factor beta 1 precursor by human furin convertase [LiteratureReference:178136] Making sense of latent TGFbeta activation |
| modified | [InstanceEdit:177394] D'Eustachio, P, 2006-03-29 14:06:52 [InstanceEdit:178131] Jassal, B, 2006-04-18 13:27:02 [InstanceEdit:1530029] Orlic-Milacic, Marija, 2011-08-25 [InstanceEdit:2197781] Orlic-Milacic, M, 2012-04-15 [InstanceEdit:2197821] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:2199153] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:9737408] Orlic-Milacic, Marija, 2021-07-19 |
| text | In the Golgi apparatus, TGF-beta-1 (TGFB1) is activated by furin protease cleavage of the N-terminal pro-peptide portion. This leads to the formation of the N-terminal disulphide-linked dimeric pro-peptides, also known as latency-associated proteins (LAPs) and the C-terminal mature disulphide-linked dimeric TGF-beta-1 (Dubois et al. 1995, Dubois et al. 2001, Leitlein et al. 2001). However, the N- and C-terminal polypeptides do not physically separate. Rather they stay in one complex. In addition, the LAP forms disulphide links with separate secreted proteins, the Latent TGF-beta binding proteins (LTBPs). LTBPs-linked to LAP and the non-covalently linked mature TGF-beta-1 remain together and form the large latent complex (LLC) (Annes et al. 2003). |
| (summation) | [Reaction:170844] Latent TGF-beta-1 is cleaved by FURIN [Homo sapiens] [Reaction:9846205] GOCAM Latent TGF-beta-1 is cleaved by FURIN [Homo sapiens] |
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No pathways have been reviewed or authored by In the Golgi apparatus, TGF-beta-1 (TGFB1) is activated by f... (176017)
