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Details on Person Formation of the hetero-tetrameric TGF-beta-1 receptor compl...
| Class:Id | Summation:176016 |
|---|---|
| _displayName | Formation of the hetero-tetrameric TGF-beta-1 receptor compl... |
| _timestamp | 2012-04-16 19:11:15 |
| created | [InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50 |
| literatureReference | [LiteratureReference:175963] Mechanism of activation of the TGF-beta receptor [LiteratureReference:175965] Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses |
| modified | [InstanceEdit:1530026] Orlic-Milacic, Marija, 2011-08-25 [InstanceEdit:2187311] Orlic-Milacic, M, 2012-04-09 [InstanceEdit:2197661] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2197781] Orlic-Milacic, M, 2012-04-15 [InstanceEdit:2199155] Orlic-Milacic, M, 2012-04-16 |
| text | Formation of the hetero-tetrameric TGF-beta-1 receptor complex induces receptor rotation, so that TGFBR2 and TGFBR1 cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain (GS domain) of the type I receptor (Wrana et al. 1994, Souchelnytskyi et al. 1996). In addition to phosphorylation, TGFBR1 may also be sumoylated in response to TGF-beta-1 stimulation. Sumoylation enhances TGFBR1 function by facilitating recruitment and phosphorylation of SMAD3 (Kang et al. 2008). |
| (summation) | [Reaction:170843] TGFBR2 phosphorylates TGFBR1 [Homo sapiens] [Reaction:9846197] GOCAM TGFBR2 phosphorylates TGFBR1 [Homo sapiens] |
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No pathways have been reviewed or authored by Formation of the hetero-tetrameric TGF-beta-1 receptor compl... (176016)
