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Details on Person The protein complex of dimeric TGF-beta-1 with the type II r...

Class:IdSummation:176012
_displayNameThe protein complex of dimeric TGF-beta-1 with the type II r...
_timestamp2023-08-21 15:32:50
created[InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50
literatureReference[LiteratureReference:177254] TGF beta signals through a heteromeric protein kinase receptor complex
[LiteratureReference:177258] The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand
[LiteratureReference:177261] Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor
[LiteratureReference:2187282] Mechanism of TGFbeta receptor inhibition by FKBP12
[LiteratureReference:3009231] Monomeric type I and type III transforming growth factor-? receptors and their dimerization revealed by single-molecule imaging
[LiteratureReference:9840108] Betaglycan presents ligand to the TGF beta signaling receptor
[LiteratureReference:9840054] Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling
modified[InstanceEdit:1530041] Orlic-Milacic, Marija, 2011-08-25
[InstanceEdit:2187284] Orlic-Milacic, M, 2012-04-08
[InstanceEdit:2197781] Orlic-Milacic, M, 2012-04-15
[InstanceEdit:2199155] Orlic-Milacic, M, 2012-04-16
[InstanceEdit:3009235] Orlic-Milacic, M, 2013-02-04
[InstanceEdit:3027887] Orlic-Milacic, M, 2013-02-05
[InstanceEdit:9842163] Tiwari, Krishna, 2023-08-21
[InstanceEdit:9842182] Orlic-Milacic, Marija, 2023-08-21
textThe protein complex of dimeric TGF-beta-1 with the type II receptor dimer (dimeric TGFB1:TGFBR2 homodimer) recruits the low affinity receptor, type I receptor (TGFBR1), thus forming a hetero-tetrameric receptor bound to the dimeric ligand on the extracellular face of the plasma membrane (TGFB1:TGFBR2:TGFBR1) (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). FKBP1A (FKBP12), a peptidyl-prolyl cis-trans isomerase, forms a complex with TGFBR1 and prevents phosphorylation of TGFBR1 by TGFBR2 in the absence of ligand. FKBP1A dissociates from TGFBR1 after it forms a complex with ligand-activated TGFBR2 (Chen et al. 1997). TGFBR1 can homodimerize in the absence of TGFB1 when overexpressed, but under physiological conditions it exists as a monomer on the surface of unstimulated cells. TGFB1-induced dimerization of TGFBR1 is TGFBR2-dependent (Zhang et al. 2010). Also, TGFBR3, a glycoprotein, binds primarily to TGFB2 and facilitates the TGFBR2 binding with its ligand and also its binding with TGFBR1 by bringing ligands in close proximity to TGFBR2 (Lopez-Casillas et al. 1993, Blobe et al. 2001).
(summation)[Reaction:170846] TGFBR2 recruits TGFBR1 [Homo sapiens]
[Reaction:9846186] GOCAM TGFBR2 recruits TGFBR1 [Homo sapiens]
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