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Details on Person HNMT transfers CH3 group from AdoMet to Hist

Class:Id	Reaction:175993
_displayName	HNMT transfers CH3 group from AdoMet to Hist
_doRelease	TRUE
_timestamp	2024-11-08 15:22:49
authored	[InstanceEdit:175989] Jassal, B, 2006-02-27 14:54:40
catalystActivity	[CatalystActivity:175990] histamine N-methyltransferase activity of HNMT [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:175989] Jassal, B, 2006-02-27 14:54:40
crossReference	[DatabaseIdentifier:9925937] RHEA:19302
edited	[InstanceEdit:6784185] Jassal, Bijay, 2015-06-18
input	[SimpleEntity:175992] Hist [cytosol] [SimpleEntity:71284] AdoMet [cytosol]
internalReviewed	[InstanceEdit:9926227] D'Eustachio, Peter, 2024-10-31
literatureReference	[LiteratureReference:5694134] Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway [LiteratureReference:5694101] Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons [LiteratureReference:5694088] The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics
modified	[InstanceEdit:5694122] Jassal, Bijay, 2015-05-21 [InstanceEdit:6783995] Jassal, Bijay, 2015-06-18 [InstanceEdit:6785238] Jassal, Bijay, 2015-06-26 [InstanceEdit:6785240] Jassal, Bijay, 2015-06-26 [InstanceEdit:6792911] Jassal, Bijay, 2015-08-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28 [InstanceEdit:9926226] D'Eustachio, Peter, 2024-10-31 [InstanceEdit:9927661] D'Eustachio, Peter, 2024-11-08
name	HNMT transfers CH3 group from AdoMet to Hist histamine + S-adenosyl-L-methionine => H(+) + N(tau)-methylhistamine + S-adenosyl-L-homocysteine Histamine is deactivated by N-methylation
output	[SimpleEntity:71285] AdoHcy [cytosol] [SimpleEntity:175991] MeHist [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:977301] Histidine is decarboxylated to histamine [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-09-22
releaseStatus	NEW
reviewed	[InstanceEdit:6785241] D'Eustachio, Peter, 2015-06-26 [InstanceEdit:9927660] D'Eustachio, Peter, 2024-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:6796618] R-HSA-175993.3
structureModified	[InstanceEdit:9925948] D'Eustachio, Peter, 2024-10-28
summation	[Summation:5694105] Histamine (Hist) plays important biological roles in cell-to...
(hasEvent)	[Pathway:70921] Histidine catabolism [Homo sapiens]
(precedingEvent)	[Reaction:9970023] AOC1 dimer oxidizes MeHist [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928448] Update Tracker - [Reaction:175993] HNMT transfers CH3 group from AdoMet to Hist - v91:[removeOutput]
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