Query author contributions in Reactome
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Details on Person The following step has been inferred from an NHEJ reaction a...
| Class:Id | Summation:175325 |
|---|---|
| _displayName | The following step has been inferred from an NHEJ reaction a... |
| _timestamp | 2006-02-27 22:43:32 |
| created | [InstanceEdit:175576] Gopinathrao, G, 2006-02-23 23:50:37 |
| modified | [InstanceEdit:176004] Gopinathrao, G, 2006-02-27 22:43:35 |
| text | The following step has been inferred from an NHEJ reaction already annotated in Reactome. Ionizing radiation induced DNA double strand breaks often contain end groups that must be processed before the DNA can be rejoined. Possible candidate proteins for the processing steps include Artemis (a nuclease) (Ma and Lieber, 2002); WRN (a helicase with exonuclease activity) (Li and Comai, 2001; Yannone et al., 2002; Karmakar, et al., 2002a, 2002b); PNK (a 5'-OH kinase and 3'-phosphate phosphatase) (Chappell et al., 2002); the Mre11/Rad50/Nbs1 nuclease complex (D' Amours and Jackson, 2002); or hTdp1 (tyrosyl-DNA phosphodiesterase, which removes 3'-glycolates)(Inamdar et al., 2002; Valerie and Povirk, 2003). Precisely when processing of the DNA ends occurs during NHEJ is not known. |
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No pathways have been reviewed or authored by The following step has been inferred from an NHEJ reaction a... (175325)
