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Details on Person UGTs transfer GlcA from UDP-GlcA to O-centre substrates

Class:Id	Reaction:174931
_displayName	UGTs transfer GlcA from UDP-GlcA to O-centre substrates
_doRelease	TRUE
_timestamp	2021-11-01 09:33:14
authored	[InstanceEdit:174926] Jassal, B, 2006-02-23 09:32:09
catalystActivity	[CatalystActivity:174915] glucuronosyltransferase activity of UGTs (O-GlcA forming) [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:174926] Jassal, B, 2006-02-23 09:32:09
edited	[InstanceEdit:174926] Jassal, B, 2006-02-23 09:32:09
input	[DefinedSet:174911] O-centre functional group substrate [endoplasmic reticulum lumen] [SimpleEntity:174384] UDP-GlcA [endoplasmic reticulum lumen]
literatureReference	[Book:76380] 9780071470513 Parkinson, A Casarett and Doull's Toxicology 5th Edn [LiteratureReference:158728] Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver. [LiteratureReference:9749993] Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes
modified	[InstanceEdit:176100] Jassal, B, 2006-03-03 15:02:05 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:351384] Jassal, B, 2008-05-22 12:43:47 [InstanceEdit:351385] Jassal, B, 2008-05-22 13:23:27 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5604980] Jassal, Bijay, 2014-07-03 [InstanceEdit:8942175] Jassal, Bijay, 2016-10-10 [InstanceEdit:8942177] Jassal, Bijay, 2016-10-10 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8954304] Jassal, Bijay, 2017-01-06 [InstanceEdit:9749991] Stephan, Ralf, 2021-08-09 [InstanceEdit:9757450] Stephan, Ralf, 2021-11-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	UGTs transfer GlcA from UDP-GlcA to O-centre substrates
output	[DefinedSet:174914] O-glucuronide [endoplasmic reticulum lumen] [SimpleEntity:158602] UDP [endoplasmic reticulum lumen]
precedingEvent	[Reaction:174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen [Homo sapiens] [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate [Homo sapiens] [Reaction:76373] N-hydroxylation of 4-aminobiphenyl [Homo sapiens] [Reaction:9749792] CES1,CES2 hydrolyze ASA- to ST [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [BlackBoxEvent:9757451] ASA-,ST translocate from cytosol to ER lumen of hepatocytes [Homo sapiens] [Reaction:9749583] SLC22A7 transports ASA-,ST from extracellular region to cytosol of hepatocytes [Homo sapiens]
releaseDate	2005-06-13
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:8954302] D'Eustachio, Peter, 2017-01-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:8942176] Jassal, Bijay, 2016-10-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359882] R-HSA-174931.5
summation	[Summation:176097] Typical O-centred substrates were chosen as examples for the...
(hasEvent)	[Pathway:156588] Glucuronidation [Homo sapiens] [Pathway:8941514] Orphan 6 events [Homo sapiens] [Pathway:9749641] Aspirin ADME [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9750713] ST metabolites diffuse out of ER lumen [BlackBoxEvent:9757459] ST metabolites diffuse out of ER lumen [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775535] Update Tracker - [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - v78:[addLiteratureReference, modifyText] [_UpdateTracker:9781869] Update Tracker - [Reaction:174931] UGTs transfer GlcA from UDP-GlcA to O-centre substrates - v60:[modifyText]
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