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Details on Person chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols

Class:Id	Reaction:174757
_displayName	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
_doRelease	TRUE
_timestamp	2017-02-16 16:16:07
authored	[InstanceEdit:197113] D'Eustachio, P, 2007-04-30 14:19:38
catalystActivity	[CatalystActivity:174759] lipoprotein lipase activity of GPIHBP1:HSPG:LPL dimer [plasma membrane]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:174717] D'Eustachio, P, 2006-02-20 17:46:54
edited	[InstanceEdit:174830] D'Eustachio, P, 2006-02-20 18:35:05
input	[Complex:174697] chylomicron [extracellular region] [Homo sapiens]
literatureReference	[LiteratureReference:174794] Comparison of apolipoprotein C-II-deficient triacylglycerol-rich lipoproteins and trioleoylglycerol/phosphatidylcholine-stabilized particles as substrates for lipoprotein lipase [LiteratureReference:174613] Human lipoprotein lipase: relationship of activity, heparin affinity, and conformation as studied with monoclonal antibodies [LiteratureReference:174715] Inhibition of lipoprotein lipase by an apoprotein of human very low density lipoprotein [LiteratureReference:174641] Lipoprotein lipase-mediated uptake of lipoprotein in human fibroblasts: evidence for an LDL receptor-independent internalization pathway [LiteratureReference:174821] Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment
modified	[InstanceEdit:174829] D'Eustachio, P, 2006-02-20 18:48:49 [InstanceEdit:177294] D'Eustachio, P, 2006-03-27 18:45:57 [InstanceEdit:197114] D'Eustachio, P, 2007-04-30 14:20:20 [InstanceEdit:216771] D'Eustachio, P, 2008-03-21 20:40:11 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8963894] D'Eustachio, Peter, 2017-02-13 [InstanceEdit:8964195] D'Eustachio, Peter, 2017-02-15 [InstanceEdit:8964415] D'Eustachio, Peter, 2017-02-16 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols
output	[Complex:174798] TG-depleted chylomicron [extracellular region] [Homo sapiens] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174675] DAGs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region] [SimpleEntity:174602] LCFAs [extracellular region]
precedingEvent	[Reaction:174660] nascent chylomicron + spherical HDL:apoC-II:apoC-III:apoE =>spherical HDL + chylomicron [Homo sapiens] [Reaction:174587] nascent chylomicron [endoplasmic reticulum lumen] => nascent chylomicron [extracellular] [Homo sapiens] [Reaction:8857928] GPIHBP1 binds HSPG:LPL dimer [Homo sapiens] [Reaction:6784861] HSPG binds LPL dimer [Homo sapiens]
regulatedBy	[PositiveRegulation:174621] Positive regulation by 'APOC2 [extracellular region]' [NegativeRegulation:174677] Negative regulation by 'APOC3 [extracellular region]' [PositiveRegulation:174695] Positive regulation by 'APOA5 [extracellular region]'
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359278] R-HSA-174757.5
summation	[Summation:174793] Lipoprotein lipase dimers (LPL:LPL) are tethered to heparan ...
(hasEvent)	[Pathway:8963901] Chylomicron remodeling [Homo sapiens]
(precedingEvent)	[Reaction:174690] TG-depleted chylomicron + spherical HDL => chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788258] Update Tracker - [Reaction:174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - v43:[modifyText] [_UpdateTracker:9788474] Update Tracker - [Reaction:174757] chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols - v42:[modifyText]
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No pathways have been reviewed or authored by chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (174757)