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Details on Person UniProt:Q6Q788 APOA5
| Class:Id | ReferenceGeneProduct:174703 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;chain:24-366 added on Fri February 6 2015 |
| _displayName | UniProt:Q6Q788 APOA5 |
| _timestamp | 2024-11-03 20:13:15 |
| chain | signal peptide:1-23 chain:24-366 |
| checksum | A1C9C207024D0DAF |
| comment | FUNCTION Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667).SUBUNIT Interacts with GPIHBP1 (PubMed:17997385). Interacts with SORL1; this interaction leads to APOA5 internalization and sorting either to lysosomes and degradation, or to the trans-Golgi network (PubMed:17326667, PubMed:18603531).INTERACTION In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network.TISSUE SPECIFICITY Liver and plasma.INDUCTION Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates).PTM Phosphorylated by FAM20C in the extracellular medium.POLYMORPHISM Three common alleles are known: allele APOA5*1, APOA5*2 and APOA5*3. The APOA5*2 haplotype, which consists of 3 non-coding SNPs, is present in approximately 16% of Caucasians and is associated with increased plasma triglyceride concentrations. APOA5*3 haplotype is defined by the rare Ser-19-Trp substitution. Together, the APOA5*2 and APOA5*3 haplotypes are found in 25 to 50% of African Americans, Hispanics, and Caucasians.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Induced in early phase of liver regeneration.SIMILARITY Belongs to the apolipoprotein A1/A4/E family.CAUTION It is uncertain whether Met-1 or Met-4 is the initiator.SEQUENCE CAUTION Truncated C-terminus. |
| created | [InstanceEdit:174717] D'Eustachio, P, 2006-02-20 17:46:54 |
| description | recommendedName: Apolipoprotein A-V shortName: Apo-AV shortName: ApoA-V alternativeName: Apolipoprotein A5 alternativeName: Regeneration-associated protein 3 |
| geneName | APOA5 RAP3 UNQ411/PRO773 |
| identifier | Q6Q788 |
| isSequenceChanged | FALSE |
| keyword | Chylomicron Coiled coil Disease variant Endosome Golgi apparatus HDL Lipid transport Phosphoprotein Proteomics identification Reference proteome Secreted Signal Transport VLDL |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | APOA5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5649922] ENSEMBL:ENSG00000110243 APOA5 [Homo sapiens] |
| secondaryIdentifier | APOA5_HUMAN B0YIV9 Q3MIK6 Q6UWK9 Q9UBJ3 |
| sequenceLength | 366 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:174608] APOA5 [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:6784664] APOA5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8956716] APOA5 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8956979] p-APOA5 [endoplasmic reticulum lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8957048] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:Q6Q788 APOA5 (174703)
