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Details on Person P4HB [endoplasmic reticulum lumen]

Class:Id	EntityWithAccessionedSequence:174692
_displayName	P4HB [endoplasmic reticulum lumen]
_timestamp	2022-09-23 20:33:47
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:174717] D'Eustachio, P, 2006-02-20 17:46:54
endCoordinate	508
modified	[InstanceEdit:1650793] Jupe, S, 2011-10-12 [InstanceEdit:2022143] Jupe, S, 2011-11-25 [InstanceEdit:9817556] D'Eustachio, Peter, 2022-09-23
name	P4HB P4HB reduced PDIA1 Protein disulfide isomerase A1
referenceEntity	[ReferenceGeneProduct:61444] UniProt:P07237 P4HB [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:370599] R-HSA-174692.2
startCoordinate	18
(hasComponent)	[Complex:174681] MTTP:PDI:lipid complex [endoplasmic reticulum lumen] [Homo sapiens] [Complex:1650765] Prolyl 4-hydroxylases [endoplasmic reticulum lumen] [Homo sapiens] [Complex:2022076] 4-Hyp collagen propeptides:P4HB [endoplasmic reticulum lumen] [Homo sapiens] [Complex:2022120] P4HB:Collagen propeptides [endoplasmic reticulum lumen] [Homo sapiens] [Complex:5490380] NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen] [Homo sapiens] [Complex:9608359] P4HB:SHH variants [endoplasmic reticulum lumen] [Homo sapiens]
(hasMember)	[DefinedSet:8956956] FAM20C substrates [endoplasmic reticulum lumen] [Homo sapiens]
(input)	[Reaction:2002460] P4HB binds Collagen chains [Homo sapiens] [Reaction:3341296] GPX7,8 catalyze peroxidation of P4HB (PDI) [Homo sapiens] [Reaction:5358336] P4HB forms mixed disulphides with Hh precursors [Homo sapiens] [Reaction:9817575] ERO1B oxidizes P4HB [Homo sapiens]
(output)	[Reaction:264997] P4HB mediates disulfide bond formation in Proinsulin [Homo sapiens] [Reaction:5358340] Autoproteolytic cleavage of Hh precursors [Homo sapiens] [BlackBoxEvent:8948234] P4HB:4-Hyp collagen propeptides dissociates [Homo sapiens]
(physicalEntity)	[CatalystActivity:2022153] protein disulfide isomerase activity of P4HB [endoplasmic reticulum lumen] [CatalystActivity:8950132] protein disulfide isomerase activity of P4HB [endoplasmic reticulum lumen]
(regulator)	[PositiveRegulation:9945584] Positive regulation by 'P4HB [endoplasmic reticulum lumen]'
(updatedInstance)	[_UpdateTracker:9871160] Update Tracker - [EntityWithAccessionedSequence:174692] P4HB [endoplasmic reticulum lumen] - v39:[modifyName] [_UpdateTracker:9905155] Update Tracker - [EntityWithAccessionedSequence:174692] P4HB [endoplasmic reticulum lumen] - v83:[modifyName]
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No pathways have been reviewed or authored by P4HB [endoplasmic reticulum lumen] (174692)