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Details on Person APOE [extracellular region]

Class:Id	EntityWithAccessionedSequence:174646
_displayName	APOE [extracellular region]
_timestamp	2013-05-28 19:19:37
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:174717] D'Eustachio, P, 2006-02-20 17:46:54
endCoordinate	317
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	APOE apoE apolipoprotein E
referenceEntity	[ReferenceGeneProduct:50124] UniProt:P02649 APOE [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:371027] R-HSA-174646.1
startCoordinate	19
(activeUnit)	[CatalystActivity:9960215] low-density lipoprotein particle receptor binding activity of APOE [extracellular region]
(hasComponent)	[Complex:174643] spherical HDL:apoC-II:apoC-III:apoE [extracellular region] [Homo sapiens] [Complex:174697] chylomicron [extracellular region] [Homo sapiens] [Complex:174792] chylomicron remnant:apoE complex [extracellular region] [Homo sapiens] [Complex:174798] TG-depleted chylomicron [extracellular region] [Homo sapiens] [Complex:174807] chylomicron remnant [extracellular region] [Homo sapiens] [Complex:2395766] CR [extracellular region] [Homo sapiens] [Complex:2395771] mature CM:atREs [extracellular region] [Homo sapiens] [Complex:2423794] CR:atREs:HSPG:apoE [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:2173760] Ligands of MSR1 [extracellular region] [Homo sapiens]
(input)	[Reaction:174739] chylomicron remnant + apoE => chylomicron remnant:apoE complex [Homo sapiens] [Reaction:266303] Spherical HDL binds C and E apolipoproteins [Homo sapiens] [Reaction:2423785] CR:atREs binds apoE and HSPG [Homo sapiens]
(output)	[BlackBoxEvent:8869590] The APOE gene transcription is stimulated by the complex of TFAP2A homodimer and DEK [Homo sapiens] [BlackBoxEvent:9031512] Expression of APOE regulated by NR1H2 or NR1H3 [Homo sapiens] [BlackBoxEvent:9612243] APOE gene transcription is stimulated by ERBB4s80 [Homo sapiens] [BlackBoxEvent:9842901] GOCAM APOE gene transcription is stimulated by ERBB4s80 [Homo sapiens]
(physicalEntity)	[CatalystActivity:9960215] low-density lipoprotein particle receptor binding activity of APOE [extracellular region]
(updatedInstance)	[_UpdateTracker:9881113] Update Tracker - [EntityWithAccessionedSequence:174646] APOE [extracellular region] - v45:[addName]
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No pathways have been reviewed or authored by APOE [extracellular region] (174646)