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Details on Person Removal of the flap by FEN1 leads to the generation of a nic...

Class:Id	Summation:174506
_displayName	Removal of the flap by FEN1 leads to the generation of a nic...
_timestamp	2019-12-11 21:05:42
created	[InstanceEdit:174505] Gillespie, ME, 2006-02-17 21:51:53
literatureReference	[LiteratureReference:69175] Completion of mammalian lagging strand DNA replication using purified proteins. [LiteratureReference:69121] Enzymes and reactions at the eucaryotic DNA replication fork. [LiteratureReference:69177] The DNA replication fork in eucaryotic cells. [LiteratureReference:69178] Interaction between PCNA and DNA ligase I is critical for joinin gof Okazaki fragments and long-patch base-excision repair. [LiteratureReference:9669358] Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells
modified	[InstanceEdit:9669363] Orlic-Milacic, Marija, 2019-12-02 [InstanceEdit:9670645] Orlic-Milacic, Marija, 2019-12-11
text	Removal of the flap by FEN1 leads to the generation of a nick between the 3'-end of the upstream Okazaki fragment and the 5'-end of the downstream Okazaki fragment. DNA ligase I (LIG1) then seals the nicks between adjacent processed Okazaki fragments to generate intact double-stranded DNA (Turchi and Bambara 1993, Bambara et al. 1997, Waga and Stillman 1998, Levin et al. 2000). LIG1 is necessary for ligation of Okazaki fragments at the lagging telomere DNA strand. LIG1 deficiency results in telomere instability, manifested through telomere sister fusions, which is a consequence of DNA breaks in the lagging strand (C-strand) (Le Chalony et al. 2012).
(summation)	[Reaction:174456] Joining of adjacent Okazaki fragments of the C-strand [Homo sapiens]
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