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Details on Person RFC binding displaces Pol Alpha on the C-strand of the telomere

Class:Id	Reaction:174452
_displayName	RFC binding displaces Pol Alpha on the C-strand of the telomere
_doRelease	TRUE
_timestamp	2022-02-22 18:20:53
authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[CandidateSet:9668941] RFC,(CFT18-RFC) [nucleoplasm] [Homo sapiens] [Complex:174433] RNA primer:DNA primer:G-strand extended telomere:POLA:primase [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:9668872] Replication factor C recognizes 5'-phosphate ends of telomeres [LiteratureReference:9668873] Characterization of telomere-binding activity of replication factor C large subunit p140
modified	[InstanceEdit:176720] Gillespie, ME, 2006-03-09 16:26:41 [InstanceEdit:176727] Gillespie, ME, 2006-03-09 19:06:16 [InstanceEdit:176736] Gillespie, ME, 2006-03-09 19:42:21 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177977] Gillespie, ME, 2006-04-13 15:15:41 [InstanceEdit:180785] Gillespie, ME, 2006-06-05 04:16:53 [InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19 [InstanceEdit:182787] Gillespie, ME, 2006-07-13 18:34:39 [InstanceEdit:183139] Gillespie, ME, 2006-07-21 18:01:36 [InstanceEdit:183148] Gopinathrao, G, 2006-07-24 03:46:25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981644] D'Eustachio, Peter, 2017-03-13 [InstanceEdit:9668877] Orlic-Milacic, Marija, 2019-11-30 [InstanceEdit:9668944] Orlic-Milacic, Marija, 2019-12-02 [InstanceEdit:9676316] Orlic-Milacic, Marija, 2020-02-12 [InstanceEdit:9686483] Orlic-Milacic, Marija, 2020-05-04 [InstanceEdit:9688867] Orlic-Milacic, Marija, 2020-05-15 [InstanceEdit:9766494] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RFC binding displaces Pol Alpha on the C-strand of the telomere
negativePrecedingEvent	[NegativePrecedingEvent:9766493] Futile Cycle: RFC dissociates after sliding clamp formation on the C-strand of the telomere
output	[Complex:68507] DNA polymerase alpha:primase [nucleoplasm] [Homo sapiens] [Complex:174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] [Homo sapiens] [Complex:9668830] CST complex [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere [Homo sapiens] [Reaction:174425] The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere [Homo sapiens] [Reaction:9668902] Formation of the CTF18-RFC(7s) complex [Homo sapiens] [Reaction:9668904] Formation of the CTF18 complex [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9672970] Gillespie, Marc E, 2020-01-03 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9671059] Orlic-Milacic, Marija, 2019-12-18
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359214] R-HSA-174452.7
summation	[Summation:69054] Once the RNA-DNA primer is synthesized, replication factor C...
(hasEvent)	[Pathway:174411] Polymerase switching on the C-strand of the telomere [Homo sapiens]
(precedingEvent)	[Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere [Homo sapiens] [NegativePrecedingEvent:9766487] Futile Cycle: RFC binding displaces Pol Alpha on the C-strand of the telomere [NegativePrecedingEvent:9766489] Futile Cycle: RFC binding displaces Pol Alpha on the C-strand of the telomere
(updatedInstance)	[_UpdateTracker:9777039] Update Tracker - [Reaction:174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - v73:[addOutput, modifyText] [_UpdateTracker:9777406] Update Tracker - [Reaction:174452] RFC binding displaces Pol Alpha on the C-strand of the telomere - v72:[addLiteratureReference, add_removeInput, modifyText]
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