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Details on Person Formation of Processive Complex on the C-strand of the telomere

Class:Id	Reaction:174448
_displayName	Formation of Processive Complex on the C-strand of the telomere
_doRelease	TRUE
_timestamp	2022-02-22 18:20:44
authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[Complex:174450] RNA primer-DNA primer:G-strand extended telomere:PCNA [nucleoplasm] [Homo sapiens] [Complex:68450] DNA Polymerase delta tetramer [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:9668885] DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation [LiteratureReference:69076] Mechanism of elongation of primed DNA by DNA polymerase delta, proliferating cell nuclear antigen, and activator 1. [LiteratureReference:69070] Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA.
modified	[InstanceEdit:176720] Gillespie, ME, 2006-03-09 16:26:41 [InstanceEdit:176727] Gillespie, ME, 2006-03-09 19:06:16 [InstanceEdit:176736] Gillespie, ME, 2006-03-09 19:42:21 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177977] Gillespie, ME, 2006-04-13 15:15:41 [InstanceEdit:180785] Gillespie, ME, 2006-06-05 04:16:53 [InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19 [InstanceEdit:182787] Gillespie, ME, 2006-07-13 18:34:39 [InstanceEdit:183139] Gillespie, ME, 2006-07-21 18:01:36 [InstanceEdit:183145] Gillespie, ME, 2006-07-21 18:37:18 [InstanceEdit:183148] Gopinathrao, G, 2006-07-24 03:46:25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981644] D'Eustachio, Peter, 2017-03-13 [InstanceEdit:8984457] Duenas, Corina, 2017-04-06 [InstanceEdit:9668890] Orlic-Milacic, Marija, 2019-12-01 [InstanceEdit:9668893] Orlic-Milacic, Marija, 2019-12-01 [InstanceEdit:9686483] Orlic-Milacic, Marija, 2020-05-04 [InstanceEdit:9766494] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Formation of Processive Complex on the C-strand of the telomere
negativePrecedingEvent	[NegativePrecedingEvent:9766491] Futile Cycle: Disassociation of Processive Complex and Completed Telomere End
output	[Complex:174453] Processive complex loaded on telomere [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:174447] RFC dissociates after sliding clamp formation on the C-strand of the telomere [Homo sapiens] [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360606] R-HSA-174448.7
summation	[Summation:9668892] The loading of proliferating cell nuclear antigen (PCNA) lea...
(hasEvent)	[Pathway:174411] Polymerase switching on the C-strand of the telomere [Homo sapiens]
(precedingEvent)	[Reaction:174444] Formation of C-strand Okazaki fragments [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776991] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v73:[modifyText] [_UpdateTracker:9777198] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v72:[add_removeLiteratureReference, add_removeSummation] [_UpdateTracker:9780992] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v61:[addLiteratureReference, modifyText] [_UpdateTracker:9783009] Update Tracker - [Reaction:174448] Formation of Processive Complex on the C-strand of the telomere - v57:[modifyText]
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