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Details on Person Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand

Class:IdReaction:174441
_displayNameRemoval of RNA primer and dissociation of RPA and Dna2 from the C-strand
_doReleaseTRUE
_timestamp2020-05-04 11:31:09
authored[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
catalystActivity[CatalystActivity:9669008] 5'-flap endonuclease activity of Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
edited[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
goBiologicalProcess[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input[Complex:174442] Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:9668993] Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition
[LiteratureReference:9669004] Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity
modified[InstanceEdit:176720] Gillespie, ME, 2006-03-09 16:26:41
[InstanceEdit:176727] Gillespie, ME, 2006-03-09 19:06:16
[InstanceEdit:176736] Gillespie, ME, 2006-03-09 19:42:21
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:177977] Gillespie, ME, 2006-04-13 15:15:41
[InstanceEdit:180785] Gillespie, ME, 2006-06-05 04:16:53
[InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19
[InstanceEdit:182787] Gillespie, ME, 2006-07-13 18:34:39
[InstanceEdit:183139] Gillespie, ME, 2006-07-21 18:01:36
[InstanceEdit:183145] Gillespie, ME, 2006-07-21 18:37:18
[InstanceEdit:183148] Gopinathrao, G, 2006-07-24 03:46:25
[InstanceEdit:418074] D'Eustachio, P, 2009-04-15 13:48:44
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8981644] D'Eustachio, Peter, 2017-03-13
[InstanceEdit:9669010] Orlic-Milacic, Marija, 2019-12-02
[InstanceEdit:9669158] Orlic-Milacic, Marija, 2019-12-02
[InstanceEdit:9686483] Orlic-Milacic, Marija, 2020-05-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRemoval of RNA primer and dissociation of RPA and Dna2 from the C-strand
output[EntityWithAccessionedSequence:68465] DNA2 [nucleoplasm] [Homo sapiens]
[Complex:174440] Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] [Homo sapiens]
[Complex:68462] RPA heterotrimer [nucleoplasm] [Homo sapiens]
[SimpleEntity:164121] AMP [nucleoplasm]
[SimpleEntity:418076] CMP [nucleoplasm]
[SimpleEntity:29626] GMP [nucleoplasm]
[SimpleEntity:418075] UMP [nucleoplasm]
precedingEvent
releaseDate2006-08-02
reviewed[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38
[InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358593] R-HSA-174441.6
summation[Summation:9669149] The DNA2 endonuclease removes the initiator RNA along with s...
(hasEvent)[Pathway:174437] Removal of the Flap Intermediate from the C-strand [Homo sapiens]
(precedingEvent)[Reaction:174446] Removal of remaining Flap from the C-strand [Homo sapiens]
[NegativePrecedingEvent:9766490] Futile Cycle: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
[NegativePrecedingEvent:9766492] Futile Cycle: Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
(updatedInstance)[_UpdateTracker:9777024] Update Tracker - [Reaction:174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - v73:[modifyText]
[_UpdateTracker:9777168] Update Tracker - [Reaction:174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - v72:[addCatalystActivity, addLiteratureReference, add_removeSummation]
[_UpdateTracker:9791523] Update Tracker - [Reaction:174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - v29:[add_removeOutput]
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