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Details on Person Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere

Class:Id	Reaction:174439
_displayName	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
_doRelease	TRUE
_timestamp	2022-02-22 18:20:50
authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
catalystActivity	[CatalystActivity:9668886] DNA clamp loader activity of RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[Complex:174454] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end [nucleoplasm] [Homo sapiens] [Complex:68440] PCNA homotrimer [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:113518] H2O [nucleoplasm]
literatureReference	[LiteratureReference:9668885] DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation [LiteratureReference:5686191] RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication
modified	[InstanceEdit:176720] Gillespie, ME, 2006-03-09 16:26:41 [InstanceEdit:176727] Gillespie, ME, 2006-03-09 19:06:16 [InstanceEdit:176736] Gillespie, ME, 2006-03-09 19:42:21 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:177977] Gillespie, ME, 2006-04-13 15:15:41 [InstanceEdit:180785] Gillespie, ME, 2006-06-05 04:16:53 [InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19 [InstanceEdit:182787] Gillespie, ME, 2006-07-13 18:34:39 [InstanceEdit:183139] Gillespie, ME, 2006-07-21 18:01:36 [InstanceEdit:183145] Gillespie, ME, 2006-07-21 18:37:18 [InstanceEdit:183148] Gopinathrao, G, 2006-07-24 03:46:25 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981644] D'Eustachio, Peter, 2017-03-13 [InstanceEdit:9668887] Orlic-Milacic, Marija, 2019-11-30 [InstanceEdit:9671187] Orlic-Milacic, Marija, 2019-12-18 [InstanceEdit:9686483] Orlic-Milacic, Marija, 2020-05-04 [InstanceEdit:9766494] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
negativePrecedingEvent	[NegativePrecedingEvent:9766486] Futile Cycle: Disassociation of Processive Complex and Completed Telomere End
output	[Complex:174449] RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113550] Pi [nucleoplasm]
precedingEvent	[Reaction:174452] RFC binding displaces Pol Alpha on the C-strand of the telomere [Homo sapiens] [Reaction:174427] The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere [Homo sapiens] [Reaction:9668902] Formation of the CTF18-RFC(7s) complex [Homo sapiens]
releaseDate	2006-08-02
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360645] R-HSA-174439.7
summation	[Summation:69064] The binding of the primer recognition complex involves the l...
(hasEvent)	[Pathway:174411] Polymerase switching on the C-strand of the telomere [Homo sapiens]
(precedingEvent)	[Reaction:174447] RFC dissociates after sliding clamp formation on the C-strand of the telomere [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776962] Update Tracker - [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - v73:[modifyText] [_UpdateTracker:9777207] Update Tracker - [Reaction:174439] Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere - v72:[addCatalystActivity, addInput, addLiteratureReference, addOutput, modifyText]
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