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Details on Person AHCY:NAD+ tetramer hydrolyses AdoHcy

Class:Id	Reaction:174401
_displayName	AHCY:NAD+ tetramer hydrolyses AdoHcy
_doRelease	TRUE
_timestamp	2024-11-27 22:46:04
catalystActivity	[CatalystActivity:174397] adenosylhomocysteinase activity of AHCY:NAD+ tetramer [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
crossReference	[DatabaseIdentifier:9929682] RHEA:21709
input	[SimpleEntity:71285] AdoHcy [cytosol] [SimpleEntity:29356] H2O [cytosol]
literatureReference	[LiteratureReference:5579074] Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength [LiteratureReference:5579036] Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions
modified	[InstanceEdit:174408] Jassal, B, 2006-02-17 11:02:06 [InstanceEdit:175984] Jassal, B, 2006-02-27 14:53:40 [InstanceEdit:176090] Jassal, B, 2006-03-03 14:06:57 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:5579090] Jassal, Bijay, 2014-06-06 [InstanceEdit:5633085] Matthews, Lisa, 2014-10-30 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929687] D'Eustachio, Peter, 2024-11-27
name	AHCY:NAD+ tetramer hydrolyses AdoHcy H2O + S-adenosyl-L-homocysteine => adenosine + L-homocysteine
output	[SimpleEntity:174369] HCYS [cytosol] [SimpleEntity:83909] Ade-Rib [cytosol]
precedingEvent	[Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP [Homo sapiens] [Reaction:76386] CYP1A2 S-demethylates 6MMP [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens] [Reaction:5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met [Homo sapiens] [Reaction:175976] TMT transfers CH3 from AdoMet to BME [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens] [Reaction:5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met [Homo sapiens] [Reaction:175987] NNMT transfers CH3 from AdoMet to PY [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens] [Reaction:5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met [Homo sapiens] [Reaction:175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens] [Reaction:5603114] MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met [Homo sapiens]
releaseDate	2005-06-13
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361356] R-HSA-174401.4
summation	[Summation:179165] Adenosylhomocysteinase (AHCY) is a tetrameric, NAD+-bound, c...
systematicName	AHCY:NAD+ tetramer hydrolyses AdoHcy, H2O to HCYS, Ade-Rib
(hasEvent)	[Pathway:156581] Methylation [Homo sapiens] [Pathway:1614635] Sulfur amino acid metabolism [Homo sapiens]
(normalReaction)	[FailedReaction:5579084] Defective AHCY does not hydrolyse AdoHcy [Homo sapiens]
(precedingEvent)	[Reaction:174374] MTR transfers CH3 from MeCbl to HCYS [Homo sapiens] [Reaction:1614524] PXLP-CBS tetramers condenses HCYS and L-Ser to form L-Cystathionine [Homo sapiens] [Reaction:1614567] Excess homocysteine yields homolanthionine and H2S [Homo sapiens] [Reaction:1614631] Homocysteine is degraded to oxobutanoate and H2S [Homo sapiens] [Reaction:1614654] BHMT tetramer transfers CH3 group from BET to HCYS to form DMGLY [Homo sapiens] [Reaction:5696838] BHMT2 tetramer transfers CH3 group from SMM to LHCYS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786102] Update Tracker - [Reaction:174401] AHCY:NAD+ tetramer hydrolyses AdoHcy - v50:[addLiteratureReference, modifyText]
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