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Details on Person GSS:Mg2+ dimer synthesizes GSH
Class:Id Reaction:174394 _displayName GSS:Mg2+ dimer synthesizes GSH _doRelease TRUE _timestamp 2016-11-10 00:55:51 catalystActivity [CatalystActivity:174399] glutathione synthase activity of GSS:Mg2+ dimer [cytosol] compartment [Compartment:70101] cytosol created [InstanceEdit:174378] Jassal, Bijay, 2006-02-17 edited [InstanceEdit:1247945] Jassal, B, 2011-04-08 input [SimpleEntity:174393] gGluCys [cytosol] [SimpleEntity:29424] Gly [cytosol] [SimpleEntity:113592] ATP [cytosol] literatureReference [LiteratureReference:1247901] Sequencing and expression of a cDNA for human glutathione synthetase [LiteratureReference:5602985] Molecular basis of glutathione synthetase deficiency and a rare gene permutation event modified [InstanceEdit:177474] Gopinathrao, G, 2006-03-30 18:08:55 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:562871] D'Eustachio, P, 2010-04-03 [InstanceEdit:1247945] Jassal, B, 2011-04-08 [InstanceEdit:1250388] Jassal, B, 2011-04-19 [InstanceEdit:5602968] Jassal, Bijay, 2014-06-25 [InstanceEdit:5633254] Matthews, Lisa, 2014-10-31 [InstanceEdit:5633399] Matthews, Lisa, 2014-10-31 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name GSS:Mg2+ dimer synthesizes GSH output [SimpleEntity:29450] GSH [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] precedingEvent
regulatedBy [NegativeRegulation:1260991] Negative regulation by 'GSH [cytosol]' regulationReference [RegulationReference:9641341] Negative regulation by 'GSH [cytosol]' Patients with genetic defects in the gamma-glutamyl cycle releaseDate 2005-06-13 reviewed [InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 reviewStatus [ReviewStatus:9821382] five stars revised [InstanceEdit:5602271] Jassal, Bijay, 2014-06-23 species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:358768] R-HSA-174394.5 summation [Summation:178803] In the second step in the formation of glutathione, gamma-gl... systematicName GSS:Mg2+ dimer synthesizes GSH (hasEvent) [Pathway:174403] Glutathione synthesis and recycling [Homo sapiens] (normalReaction) [FailedReaction:5602901] Defective GSS does not synthesize GSH [Homo sapiens] (precedingEvent) [Reaction:176054] GST dimers conjugate GSH with cytosolic substrates [Homo sapiens] [Reaction:176059] GST trimers transfer GS from GSH to luminal substrates [Homo sapiens] [BlackBoxEvent:1247915] GSH translocates from cytosol to extracellular region [Homo sapiens] [Reaction:6785928] CHAC1,2 cleaves GSH to OPRO and CysGly [Homo sapiens] [Reaction:9753280] GSTs transfer GSH to NAPQI to form APAP-SG [Homo sapiens] (updatedInstance) [_UpdateTracker:9786132] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v50:[addLiteratureReference, modifyText] [_UpdateTracker:9789611] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v37:[addLiteratureReference, addRegulator, modifyText] [_UpdateTracker:9790721] Update Tracker - [Reaction:174394] GSS:Mg2+ dimer synthesizes GSH - v33:[addInput]
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No pathways have been reviewed or authored by GSS:Mg2+ dimer synthesizes GSH (174394)
