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Details on Person PAPSS1,2 transfer SO4(2-) group to ATP to form APS

Class:Id	Reaction:174392
_displayName	PAPSS1,2 transfer SO4(2-) group to ATP to form APS
_doRelease	TRUE
_timestamp	2025-03-07 10:45:39
catalystActivity	[CatalystActivity:174381] sulfate adenylyltransferase (ATP) activity of PAPSS1,2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
crossReference	[DatabaseIdentifier:9941489] RHEA:18134
goBiologicalProcess	[GO_BiologicalProcess:80800] 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:174375] SO4(2-) [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:176622] Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase [LiteratureReference:176653] Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse [LiteratureReference:176713] Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains
modified	[InstanceEdit:176534] D'Eustachio, P, 2006-03-08 20:43:01 [InstanceEdit:176709] D'Eustachio, P, 2006-03-09 16:08:49 [InstanceEdit:177298] D'Eustachio, P, 2006-03-27 19:02:00 [InstanceEdit:211329] D'Eustachio, P, 2008-01-31 16:24:38 [InstanceEdit:3465593] Jassal, Bijay, 2013-05-17 [InstanceEdit:3465601] Jassal, Bijay, 2013-05-17 [InstanceEdit:3465603] Jassal, Bijay, 2013-05-17 [InstanceEdit:5607069] Jassal, Bijay, 2014-07-10 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9774141] D'Eustachio, Peter, 2022-05-18 [InstanceEdit:9774142] D'Eustachio, Peter, 2022-05-18 [InstanceEdit:9774233] D'Eustachio, Peter, 2022-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941465] Stephan, Ralf, 2025-03-07
name	PAPSS1,2 transfer SO4(2-) group to ATP to form APS ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate Activation of inorganic sulfate forms APS
output	[SimpleEntity:174370] APS [cytosol] [SimpleEntity:111294] PPi [cytosol]
precedingEvent	[Reaction:427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol [Homo sapiens] [Reaction:425577] Na+-driven Cl-/HCO3- exchanger transport [Homo sapiens] [Reaction:9941470] SLC26A11 imports SO4(2-) and H+ into cytosol [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:9774232] Hill, David P, 2022-05-19
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9774231] D'Eustachio, Peter, 2022-05-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359814] R-HSA-174392.5
summation	[Summation:176662] In the first step of PAPS biosynthesis, ATP and sulfate reac...
(hasEvent)	[Pathway:174362] Transport and metabolism of PAPS [Homo sapiens]
(inferredFrom)	[Reaction:1113168] ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate [Oryza sativa]
(normalReaction)	[FailedReaction:3560794] Defective PAPSS2 does not transfer SO4(2-) group to ATP to form APS [Homo sapiens]
(orthologousEvent)	[Reaction:1113168] ATP + sulfate => adenylyl sulfate (APS) + pyrophosphate [Oryza sativa]
(precedingEvent)	[Reaction:71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Homo sapiens] [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786165] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v50:[modifyText] [_UpdateTracker:9787312] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v45:[modifyText] [_UpdateTracker:9846990] Update Tracker - [Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS - v82:[addInput]
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