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Details on Person PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS

Class:Id	Reaction:174389
_displayName	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS
_doRelease	TRUE
_timestamp	2025-03-07 10:45:29
catalystActivity	[CatalystActivity:174366] adenylylsulfate kinase activity of PAPSS1,2 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
crossReference	[DatabaseIdentifier:9941469] RHEA:24153
goBiologicalProcess	[GO_BiologicalProcess:80800] 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:174370] APS [cytosol]
literatureReference	[LiteratureReference:176653] Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse [LiteratureReference:176622] Sulfation in high endothelial venules: cloning and expression of the human PAPS synthetase [LiteratureReference:176713] Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains
modified	[InstanceEdit:176534] D'Eustachio, P, 2006-03-08 20:43:01 [InstanceEdit:176709] D'Eustachio, P, 2006-03-09 16:08:49 [InstanceEdit:177298] D'Eustachio, P, 2006-03-27 19:02:00 [InstanceEdit:211329] D'Eustachio, P, 2008-01-31 16:24:38 [InstanceEdit:2121206] Matthews, L, 2012-02-13 [InstanceEdit:3465593] Jassal, Bijay, 2013-05-17 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9774141] D'Eustachio, Peter, 2022-05-18 [InstanceEdit:9774142] D'Eustachio, Peter, 2022-05-18 [InstanceEdit:9774233] D'Eustachio, Peter, 2022-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9941465] Stephan, Ralf, 2025-03-07
name	PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS adenylyl sulfate (APS) + ATP => PAPS + ADP APS reacts with another ATP molecule to form PAPS
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:158471] PAPS [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:174392] PAPSS1,2 transfer SO4(2-) group to ATP to form APS [Homo sapiens] [Reaction:427555] SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol [Homo sapiens] [Reaction:9941470] SLC26A11 imports SO4(2-) and H+ into cytosol [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:9774232] Hill, David P, 2022-05-19
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:9774231] D'Eustachio, Peter, 2022-05-19
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359722] R-HSA-174389.5
summation	[Summation:176543] In the second step of PAPS biosynthesis, adenylyl sulfate (A...
(hasEvent)	[Pathway:174362] Transport and metabolism of PAPS [Homo sapiens]
(normalReaction)	[FailedReaction:3560785] Defective PAPSS2 does not transfer PO4(2-) group from ATP to APS to form PAPS [Homo sapiens]
(precedingEvent)	[Reaction:158468] SULT1A1 dimer sulfonates PARA to PARA-SO4 [Homo sapiens] [Reaction:158849] Phenol can form a sulfate conjugate [Homo sapiens] [Reaction:158860] SULT1A1 dimer sulfonates NHABP [Homo sapiens] [Reaction:159358] SULT1A3,4 dimers sulfate DA to DAOS [Homo sapiens] [Reaction:176474] 3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP [Homo sapiens] [Reaction:176494] SULTs transfer (SO4)2- group to 27HCHOL [Homo sapiens] [Reaction:176517] SULTs transfer (SO4)2- group to PREG [Homo sapiens] [Reaction:176521] beta-estradiol + PAPS => beta-estradiol 3-sulfate + PAP [Homo sapiens] [Reaction:176585] 3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP [Homo sapiens] [Reaction:176588] lithocholate + PAPS => lithocholate sulfate + PAP [Homo sapiens] List all 17 refering instances
(updatedInstance)	[_UpdateTracker:9786049] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v50:[modifyText] [_UpdateTracker:9787321] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v45:[modifyText] [_UpdateTracker:9846973] Update Tracker - [Reaction:174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - v82:[addOutput]
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