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Details on Person MTR transfers CH3 from MeCbl to HCYS

Class:Id	Reaction:174374
_displayName	MTR transfers CH3 from MeCbl to HCYS
_doRelease	TRUE
_timestamp	2022-02-14 15:47:10
authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:174360] methionine synthase activity of MTRR:MTR:MeCbl [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
edited	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17
input	[Complex:3149551] MTRR:MTR:MeCbl [cytosol] [Homo sapiens] [SimpleEntity:174369] HCYS [cytosol]
literatureReference	[LiteratureReference:9759623] Interaction of flavodoxin with cobalamin-dependent methionine synthase [LiteratureReference:200732] Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
modified	[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:200727] D'Eustachio, P, 2007-07-23 20:23:04 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:3159299] Jassal, Bijay, 2013-02-20 [InstanceEdit:3160768] Jassal, B, 2013-02-20 [InstanceEdit:3162930] Jassal, Bijay, 2013-02-21 [InstanceEdit:3928680] Jassal, Bijay, 2013-07-23 [InstanceEdit:5603083] Jassal, Bijay, 2014-06-27 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9644853] Jassal, Bijay, 2019-04-25 [InstanceEdit:9759628] D'Eustachio, Peter, 2021-12-08 [InstanceEdit:9764259] D'Eustachio, Peter, 2022-02-10 [InstanceEdit:9764875] D'Eustachio, Peter, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MTR transfers CH3 from MeCbl to HCYS Methionine is reformed
negativePrecedingEvent	[NegativePrecedingEvent:9764871] Futile Cycle: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin
output	[Complex:3149516] MTRR:MTR:cob(I)alamin [cytosol] [Homo sapiens] [SimpleEntity:174390] L-Met [cytosol]
precedingEvent	[Reaction:200676] MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG [Homo sapiens] [Reaction:200718] MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG [Homo sapiens] [Reaction:200735] SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG [Homo sapiens] [Reaction:200681] FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG [Homo sapiens] [Reaction:200652] SLC19A1 transports 5-methyl-THF from extracellular region to cytosol [Homo sapiens] [Reaction:174401] AHCY:NAD+ tetramer hydrolyses AdoHcy [Homo sapiens] [Reaction:158609] TPMT transfers CH3 from AdoMet to 6MP [Homo sapiens] [Reaction:175976] TMT transfers CH3 from AdoMet to BME [Homo sapiens] [Reaction:175987] NNMT transfers CH3 from AdoMet to PY [Homo sapiens] [Reaction:175983] COMT transfer CH3 from AdoMet to 3,4DHBNZ [Homo sapiens] [Reaction:3160769] MTR transfers CH3 from MTHFPG to B12s [Homo sapiens] [Reaction:3149518] MTRR reduces cob(II)alamin to meCbl [Homo sapiens] [Reaction:3149518] MTRR reduces cob(II)alamin to meCbl [Homo sapiens] [BlackBoxEvent:3204318] cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:3162924] Jassal, B, 2013-02-21
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361654] R-HSA-174374.5
summation	[Summation:3149512] Methionine synthase (MTR) mediates the continuous shuttling ...
(hasEvent)	[Pathway:156581] Methylation [Homo sapiens] [Pathway:1614635] Sulfur amino acid metabolism [Homo sapiens] [Pathway:9759218] Cobalamin (Cbl) metabolism [Homo sapiens]
(normalReaction)	[FailedReaction:3322140] Defective MTR does not transfer CH3 group from MeCbl to HCYS [Homo sapiens]
(precedingEvent)	[Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens] [Reaction:3149539] MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775069] Update Tracker - [Reaction:174374] MTR transfers CH3 from MeCbl to HCYS - v80:[addLiteratureReference, modifyText] [_UpdateTracker:9787133] Update Tracker - [Reaction:174374] MTR transfers CH3 from MeCbl to HCYS - v46:[add_removeOutput, modifyText] [_UpdateTracker:9787507] Update Tracker - [Reaction:174374] MTR transfers CH3 from MeCbl to HCYS - v45:[modifyText] [_UpdateTracker:9787718] Update Tracker - [Reaction:174374] MTR transfers CH3 from MeCbl to HCYS - v44:[add_removeInput, add_removeOutput, add_removeSummation] [_UpdateTracker:9792302] Update Tracker - [Reaction:174374] MTR transfers CH3 from MeCbl to HCYS - v22:[addLiteratureReference, add_removeOutput, modifyText]
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