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Details on Person Degradation multiubiquitinated Cyclin A

Class:Id	BlackBoxEvent:174255
_displayName	Degradation multiubiquitinated Cyclin A
_doRelease	TRUE
_timestamp	2016-11-10 00:54:28
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:176469] Matthews, L, 2006-03-07 23:53:31
goBiologicalProcess	[GO_BiologicalProcess:160432] proteasome-mediated ubiquitin-dependent protein catabolic process
input	[Complex:174222] multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
modified	[InstanceEdit:176824] Matthews, L, 2006-03-13 00:06:48 [InstanceEdit:176926] Matthews, L, 2006-03-16 21:32:37 [InstanceEdit:177343] Matthews, L, 2006-03-28 00:20:46 [InstanceEdit:177824] Matthews, L, 2006-04-10 08:37:24 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Degradation multiubiquitinated Cyclin A
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:157415] p-T161-CDK1 [cytosol] [Homo sapiens] [Complex:141410] MCC:APC/C complex [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex [Homo sapiens] [Reaction:174171] Association of Cyclin A with the APC/C [Homo sapiens] [Reaction:141423] Binding of the MCC complex to the APC/C complex [Homo sapiens]
releaseDate	2005-06-13
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360671] R-HSA-174255.3
summation	[Summation:176897] Following multiubiquitination, Cyclin A is targeted for dest...
(hasEvent)	[Pathway:174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A [Homo sapiens]
(precedingEvent)	[Reaction:174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 [Homo sapiens] [NegativePrecedingEvent:9764076] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764077] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764080] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764081] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764083] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764139] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764147] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764148] Futile Cycle: Degradation multiubiquitinated Cyclin A
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No pathways have been reviewed or authored by Degradation multiubiquitinated Cyclin A (174255)