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Details on Person Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1

Class:Id	Reaction:174238
_displayName	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
_doRelease	TRUE
_timestamp	2022-02-08 22:57:57
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:156512] Matthews, L, 2004-11-18 13:25:08 [InstanceEdit:173835] Matthews, L, 2006-02-17 00:25:47
goBiologicalProcess	[GO_BiologicalProcess:3446115] regulation of mitotic cell cycle phase transition
input	[Complex:141410] MCC:APC/C complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:143450] Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
modified	[InstanceEdit:176821] Matthews, L, 2006-03-13 00:05:50 [InstanceEdit:177312] Matthews, L, 2006-03-28 00:15:04 [InstanceEdit:177817] Matthews, L, 2006-04-09 22:38:08 [InstanceEdit:177824] Matthews, L, 2006-04-10 08:37:24 [InstanceEdit:177971] Matthews, L, 2006-04-13 06:30:46 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9617267] Matthews, Lisa, 2018-08-17 [InstanceEdit:9764149] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
negativePrecedingEvent	[NegativePrecedingEvent:9764146] Futile Cycle: Degradation of multiubiquitinated Nek2A
output	[Complex:174196] hBUBR1:hBUB3:MAD2* complex [cytosol] [Homo sapiens] [Complex:174081] CDC20:p-APC/C [cytosol] [Homo sapiens]
precedingEvent	[Reaction:141423] Binding of the MCC complex to the APC/C complex [Homo sapiens] [Reaction:141437] Formation of the MCC complex [Homo sapiens] [BlackBoxEvent:174255] Degradation multiubiquitinated Cyclin A [Homo sapiens] [Reaction:174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex [Homo sapiens]
releaseDate	2005-06-13
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359876] R-HSA-174238.5
summation	[Summation:176817] One model ( the direct inhibition model) describing the inhi...
(hasEvent)	[Pathway:176409] APC/C:Cdc20 mediated degradation of mitotic proteins [Homo sapiens]
(inferredFrom)	[Reaction:1113090] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 [Oryza sativa]
(orthologousEvent)	[Reaction:1113090] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 [Oryza sativa]
(precedingEvent)	[Reaction:174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex [Homo sapiens] [Reaction:174121] Association of Securin with Cdc20:APC/C complex [Homo sapiens] [Reaction:174224] Dissociation of Cdc20 from APC/C complex [Homo sapiens]
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No pathways have been reviewed or authored by Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (174238)