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Details on Person Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex

Class:IdReaction:174227
_displayNameUbiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
_doReleaseTRUE
_timestamp2022-02-08 22:53:07
authored[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity[CatalystActivity:9764125] ubiquitin-protein transferase activity of Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
goBiologicalProcess[GO_BiologicalProcess:7441] ubiquitin-dependent protein catabolic process
input[Complex:174095] Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
modified[InstanceEdit:177374] Matthews, L, 2006-03-28 00:29:44
[InstanceEdit:177822] Matthews, L, 2006-04-09 23:12:52
[InstanceEdit:177824] Matthews, L, 2006-04-10 08:37:24
[InstanceEdit:186980] Matthews, L, 2006-09-05 23:27:11
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9764086] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764098] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764110] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764118] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764126] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764136] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameUbiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
negativePrecedingEvent[NegativePrecedingEvent:9764077] Futile Cycle: Degradation multiubiquitinated Cyclin A
[NegativePrecedingEvent:9764095] Futile Cycle: Degradation of multiubiquitinated Nek2A
[NegativePrecedingEvent:9764103] Futile Cycle: Degradation of multiubiquitinated cell cycle proteins
[NegativePrecedingEvent:9764117] Futile Cycle: SCF-mediated degradation of Emi1
[NegativePrecedingEvent:9764131] Futile Cycle: Degradation of multiubiquitinated Cyclin B
[NegativePrecedingEvent:9764134] Futile Cycle: Degradation of multiubiquitinated Securin
output[Complex:174131] multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] [Homo sapiens]
precedingEvent
releaseDate2006-04-24
reviewed[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360107] R-HSA-174227.4
summation[Summation:179283] At the beginning of this reaction, 1 molecule of 'Cdc20:phos...
(hasEvent)[Pathway:174048] APC/C:Cdc20 mediated degradation of Cyclin B [Homo sapiens]
(precedingEvent)[BlackBoxEvent:174157] Degradation of multiubiquitinated Cyclin B [Homo sapiens]
(updatedInstance)[_UpdateTracker:9775010] Update Tracker - [Reaction:174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex - v80:[add_removeCatalystActivity]
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