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Details on Person SCF-mediated degradation of Emi1

Class:Id	BlackBoxEvent:174203
_displayName	SCF-mediated degradation of Emi1
_doRelease	TRUE
_timestamp	2016-11-10 00:54:30
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
input	[Complex:174061] SCF-associated multiubiquitinated Emi1complexes [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:163011] Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1
modified	[InstanceEdit:176463] Matthews, L, 2006-03-07 23:51:52 [InstanceEdit:177369] Matthews, L, 2006-03-28 00:28:36 [InstanceEdit:177972] Matthews, L, 2006-04-13 06:31:15 [InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SCF-mediated degradation of Emi1
output	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [Complex:174155] BTRC:CUL1:SKP1 [cytosol] [Homo sapiens] [DefinedSet:177320] Cdc20/Cdh1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:174159] Ubiquitination of Emi1 by SCF-beta-TrCP [Homo sapiens] [Reaction:174209] Phosphorylated Emi1 binds the beta-TrCP in the SCF complex [Homo sapiens]
releaseDate	2006-04-24
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361182] R-HSA-174203.3
summation	[Summation:176428] Multiubiquitinated Emi1 is degraded by the 26S proteasome.
(hasEvent)	[Pathway:174113] SCF-beta-TrCP mediated degradation of Emi1 [Homo sapiens]
(precedingEvent)	[Reaction:174251] Phosphorylation of Cdh1 by Cyclin B1:Cdc2 [Homo sapiens] [NegativePrecedingEvent:9764111] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9764113] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9764115] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9764116] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9764117] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9764132] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9766468] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9766469] Futile Cycle: SCF-mediated degradation of Emi1 [NegativePrecedingEvent:9766470] Futile Cycle: SCF-mediated degradation of Emi1 List all 12 refering instances
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No pathways have been reviewed or authored by SCF-mediated degradation of Emi1 (174203)