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Details on Person Phosphorylation of the Emi1 DSGxxS degron by Plk1

Class:Id	Reaction:174174
_displayName	Phosphorylation of the Emi1 DSGxxS degron by Plk1
_doRelease	TRUE
_timestamp	2016-11-10 00:54:34
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
catalystActivity	[CatalystActivity:156714] protein serine/threonine kinase activity of p-T210-PLK1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:174297] Matthews, L, 2006-02-17 05:22:55
input	[SimpleEntity:29358] ATP [nucleoplasm] [SimpleEntity:29358] ATP [nucleoplasm] [Complex:188679] Emi1:Cdc20/Cdh1 complex [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:163011] Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1
modified	[InstanceEdit:176462] Matthews, L, 2006-03-07 23:51:35 [InstanceEdit:177367] Matthews, L, 2006-03-28 00:28:05 [InstanceEdit:177972] Matthews, L, 2006-04-13 06:31:15 [InstanceEdit:188681] Matthews, L, 2006-10-23 05:47:42 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of the Emi1 DSGxxS degron by Plk1
output	[SimpleEntity:113582] ADP [nucleoplasm] [SimpleEntity:113582] ADP [nucleoplasm] [Complex:176446] phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:174235] Association of Emi1 with Cdc20 [Homo sapiens] [Reaction:174097] Association of Emi1 with Cdh1 [Homo sapiens]
releaseDate	2006-04-24
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360518] R-HSA-174174.3
summation	[Summation:176441] The phosphorylation of Emi1 by Plk1 is believed to be involv...
(hasEvent)	[Pathway:176417] Phosphorylation of Emi1 [Homo sapiens]
(precedingEvent)	[Reaction:174209] Phosphorylated Emi1 binds the beta-TrCP in the SCF complex [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylation of the Emi1 DSGxxS degron by Plk1 (174174)