Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Association of Cyclin A with the APC/C

Class:Id	Reaction:174171
_displayName	Association of Cyclin A with the APC/C
_doRelease	TRUE
_timestamp	2022-02-08 22:57:59
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:176455] Matthews, L, 2006-03-07 23:49:09
input	[Complex:141410] MCC:APC/C complex [cytosol] [Homo sapiens] [Complex:174232] Cyclin A:phospho-Cdc2(Thr 161) complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:174080] Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex [LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
modified	[InstanceEdit:176459] Matthews, L, 2006-03-07 23:50:45 [InstanceEdit:176822] Matthews, L, 2006-03-13 00:06:11 [InstanceEdit:176894] Matthews, L, 2006-03-16 20:47:28 [InstanceEdit:177319] Matthews, L, 2006-03-28 00:15:58 [InstanceEdit:177818] Matthews, L, 2006-04-09 22:41:45 [InstanceEdit:177972] Matthews, L, 2006-04-13 06:31:15 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9637739] Orlic-Milacic, Marija, 2019-02-19 [InstanceEdit:9764149] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of Cyclin A with the APC/C
negativePrecedingEvent	[NegativePrecedingEvent:9764139] Futile Cycle: Degradation multiubiquitinated Cyclin A [NegativePrecedingEvent:9764137] Futile Cycle: Degradation of multiubiquitinated Nek2A
output	[Complex:174140] Cdc2:Cyclin A:MCC:APC/C complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:141423] Binding of the MCC complex to the APC/C complex [Homo sapiens] [Reaction:141437] Formation of the MCC complex [Homo sapiens]
releaseDate	2005-04-11
requiredInputComponent	[EntityWithAccessionedSequence:141412] CDC20 [cytosol] [Homo sapiens] [CandidateSet:170089] CCNA [cytosol] [Homo sapiens]
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359484] R-HSA-174171.5
summation	[Summation:176895] Cyclin A is believed to be recognized by the APC/C:Cdc20 com...
(hasEvent)	[Pathway:174184] Cdc20:Phospho-APC/C mediated degradation of Cyclin A [Homo sapiens]
(precedingEvent)	[Reaction:174104] Ubiquitination of Cyclin A by APC/C:Cdc20 complex [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by Association of Cyclin A with the APC/C (174171)