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Details on Person Phosphorylation of Cyclin A:Cdk2 at Tyr 15

Class:Id	Reaction:174164
_displayName	Phosphorylation of Cyclin A:Cdk2 at Tyr 15
_doRelease	TRUE
_timestamp	2022-02-08 21:34:56
authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity	[CatalystActivity:69254] protein tyrosine kinase activity of WEE1 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:187878] Matthews, L, 2006-09-28 04:25:14
input	[Complex:141608] CCNA:CDK2 [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:187925] Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15 [LiteratureReference:213358] Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
modified	[InstanceEdit:176439] Matthews, L, 2006-03-07 23:45:39 [InstanceEdit:177333] Matthews, L, 2006-03-28 00:18:21 [InstanceEdit:177753] Matthews, L, 2006-04-04 22:33:15 [InstanceEdit:177818] Matthews, L, 2006-04-09 22:41:45 [InstanceEdit:187983] Matthews, L, 2006-09-29 14:03:09 [InstanceEdit:188395] Matthews, L, 2006-10-10 14:00:29 [InstanceEdit:188514] Matthews, L, 2006-10-17 04:39:16 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9605536] Orlic-Milacic, Marija, 2018-04-13 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9764012] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Cyclin A:Cdk2 at Tyr 15
negativePrecedingEvent	[NegativePrecedingEvent:9764011] Futile Cycle: Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2
output	[Complex:187907] CCNA:p-Y15-CDK2 [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus [Homo sapiens] [Reaction:174054] Formation of Cyclin A:Cdk2 complexes [Homo sapiens]
regulatedBy	[PositiveRegulation:9605537] Positive regulation by 'CABLES1 [nucleoplasm]'
regulationReference	[RegulationReference:9642766] Positive regulation by 'CABLES1 [nucleoplasm]' Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers
releaseDate	2006-11-16
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358376] R-HSA-174164.6
summation	[Summation:187984] The CDK activity of the Cyclin A:Cdk2 complex is inhibited b...
(hasEvent)	[Pathway:69656] Cyclin A:Cdk2-associated events at S phase entry [Homo sapiens]
(precedingEvent)	[Reaction:174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779347] Update Tracker - [Reaction:174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - v65:[addLiteratureReference, addRegulator, modifyText]
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