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Details on Person Association of Securin with Cdc20:APC/C complex

Class:Id	Reaction:174121
_displayName	Association of Securin with Cdc20:APC/C complex
_doRelease	TRUE
_timestamp	2022-02-08 22:58:04
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
input	[Complex:174081] CDC20:p-APC/C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174190] PTTG1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:174096] Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1
modified	[InstanceEdit:176902] Matthews, L, 2006-03-16 20:51:53 [InstanceEdit:177334] Matthews, L, 2006-03-28 00:18:39 [InstanceEdit:177818] Matthews, L, 2006-04-09 22:41:45 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9764075] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9764149] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of Securin with Cdc20:APC/C complex
negativePrecedingEvent	[NegativePrecedingEvent:9764071] Futile Cycle: Degradation of multiubiquitinated Securin [NegativePrecedingEvent:9764142] Futile Cycle: Degradation of multiubiquitinated Cyclin B
output	[Complex:174212] CDC20:p-APC/C:PTTG1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 [Homo sapiens] [Reaction:141423] Binding of the MCC complex to the APC/C complex [Homo sapiens] [BlackBoxEvent:174255] Degradation multiubiquitinated Cyclin A [Homo sapiens]
releaseDate	2005-04-11
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359880] R-HSA-174121.4
summation	[Summation:176905] Securin is thought to be recognized by the APC/C:Cdc20 compl...
(hasEvent)	[Pathway:174154] APC/C:Cdc20 mediated degradation of Securin [Homo sapiens] [Pathway:2467813] Separation of Sister Chromatids [Homo sapiens]
(precedingEvent)	[Reaction:174144] Ubiquitination of Securin by phospho-APC/C:Cdc20 complex [Homo sapiens]
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No pathways have been reviewed or authored by Association of Securin with Cdc20:APC/C complex (174121)