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Details on Person Association of Cyclin B:Cdc2 with Cdc20:APC/C complex

Class:Id	Reaction:174120
_displayName	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
_doRelease	TRUE
_timestamp	2022-02-08 22:58:01
authored	[InstanceEdit:174241] Lorca, T, Castro, A, 2006-01-26 00:00:00
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:174149] Matthews, L, 2006-02-17 00:41:48
edited	[InstanceEdit:174183] Matthews, L, 2006-01-30 00:00:00
input	[Complex:174081] CDC20:p-APC/C [cytosol] [Homo sapiens] [Complex:157456] CCNB1:p-T161-CDK1 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:174075] Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
modified	[InstanceEdit:176425] Matthews, L, 2006-03-07 23:44:14 [InstanceEdit:177323] Matthews, L, 2006-03-28 00:16:23 [InstanceEdit:177818] Matthews, L, 2006-04-09 22:41:45 [InstanceEdit:178126] Matthews, L, 2006-04-17 23:40:42 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8984052] Varusai, Thawfeek, 2017-04-04 [InstanceEdit:9764149] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
negativePrecedingEvent	[NegativePrecedingEvent:9764143] Futile Cycle: Degradation of multiubiquitinated Cyclin B [NegativePrecedingEvent:9764138] Futile Cycle: Degradation of multiubiquitinated Securin
output	[Complex:174095] Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:174238] Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 [Homo sapiens] [Reaction:141423] Binding of the MCC complex to the APC/C complex [Homo sapiens] [BlackBoxEvent:174255] Degradation multiubiquitinated Cyclin A [Homo sapiens] [Reaction:170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases [Homo sapiens] [Reaction:170159] Translocation of Cdc25 to the nucleus [Homo sapiens] [Reaction:170131] Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes [Homo sapiens] [Reaction:156699] Inactivation of Wee1 kinase [Homo sapiens] [BlackBoxEvent:4088152] FOXM1 stimulates CDC25A transcription [Homo sapiens] [Reaction:170044] Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus [Homo sapiens] [Reaction:170149] Translocation of active Cdc25C to the nucleus [Homo sapiens] [Reaction:170070] Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes [Homo sapiens]
releaseDate	2005-09-26
reviewed	[InstanceEdit:177300] Peters, JM, 2006-03-27 22:55:09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359419] R-HSA-174120.5
summation	[Summation:177325] Cyclin B is believed to be recognized by the APC/C:Cdc20 com...
(hasEvent)	[Pathway:174048] APC/C:Cdc20 mediated degradation of Cyclin B [Homo sapiens]
(precedingEvent)	[Reaction:174227] Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9780950] Update Tracker - [Reaction:174120] Association of Cyclin B:Cdc2 with Cdc20:APC/C complex - v61:[addLiteratureReference]
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No pathways have been reviewed or authored by Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (174120)