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Details on Person RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers

Class:Id	Reaction:173769
_displayName	RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
_doRelease	TRUE
_timestamp	2014-08-29 21:16:41
authored	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
catalystActivity	[CatalystActivity:182891] RNA-DNA hybrid ribonuclease activity of RTC with extending second-strand DNA [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:173765] Gopinathrao, G, 2006-02-16 23:18:33
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
edited	[InstanceEdit:180401] Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
figure	[Figure:180426] /figures/RT_event6.jpg
input	[Complex:182880] RTC with extending second-strand DNA [cytosol] [Homo sapiens]
literatureReference	[Book:175762] 9780879695712 Reverse Transcriptase and the Generation of Retroviral DNA Retroviruses Coffin, JM [LiteratureReference:177456] Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase [LiteratureReference:175646] The HIV-1 reverse transcription (RT) process as target for RT inhibitors
modified	[InstanceEdit:174501] Gopinathrao, G, 2006-02-17 21:37:08 [InstanceEdit:175576] Gopinathrao, G, 2006-02-23 23:50:37 [InstanceEdit:175638] Gopinathrao, G, 2006-02-25 14:03:09 [InstanceEdit:176402] Gopinathrao, G, 2006-03-07 21:34:46 [InstanceEdit:176403] Gopinathrao, G, 2006-03-07 21:38:38 [InstanceEdit:176739] Gopinathrao, G, 2006-03-10 15:27:37 [InstanceEdit:177399] Gopinathrao, G, 2006-03-29 16:14:14 [InstanceEdit:177417] D'Eustachio, P, 2006-03-30 15:26:43 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:180402] Gopinathrao, G, 2006-05-18 20:43:08 [InstanceEdit:180425] Gopinathrao, G, 2006-05-19 20:14:37 [InstanceEdit:180480] Gopinathrao, G, 2006-05-21 12:01:35 [InstanceEdit:182677] Gopinathrao, G, 2006-07-12 03:00:19 [InstanceEdit:182820] Gopinathrao, G, 2006-07-19 16:21:19 [InstanceEdit:182879] Gopinathrao, G, 2006-07-19 18:45:47 [InstanceEdit:182881] Gopinathrao, G, 2006-07-19 19:07:52 [InstanceEdit:182884] Gopinathrao, G, 2006-07-20 15:11:27 [InstanceEdit:182890] Gopinathrao, G, 2006-07-20 19:02:21 [InstanceEdit:182896] D'Eustachio, P, 2006-07-20 20:33:15 [InstanceEdit:184166] Gopinathrao, G, 2006-07-25 04:37:17 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188941] Gopinathrao, G, 2006-10-30 22:24:14 [InstanceEdit:188963] Gopinathrao, G, 2006-11-01 22:14:37 [InstanceEdit:352524] D'Eustachio, P, 2008-06-03 19:07:14 [InstanceEdit:3632906] Gillespie, ME, 2013-05-28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
output	[Complex:173824] RTC without viral RNA template [cytosol] [Homo sapiens]
precedingEvent	[Reaction:164513] 3' PPT-primed initiation of plus-strand DNA synthesis [Homo sapiens] [Reaction:182795] RNase H-mediated degradation of the template strand [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-11-14
reviewed	[InstanceEdit:188936] Hughes, SH, 2006-10-30 22:00:51
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358458] R-HSA-173769.2
summation	[Summation:177430] RNase H catalyzes the precise cleavage of the bonds linking ...
(hasEvent)	[Pathway:164525] Plus-strand DNA synthesis [Homo sapiens]
(precedingEvent)	[Reaction:164512] Second strand transfer by annealing complementary PBS sequences [Homo sapiens]
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No pathways have been reviewed or authored by RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers (173769)