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Details on Person UDP-glucose is oxidised to UDP-glucuronate

Class:Id	Reaction:173597
_displayName	UDP-glucose is oxidised to UDP-glucuronate
_doRelease	TRUE
_timestamp	2024-07-19 18:51:06
authored	[InstanceEdit:173596] Jassal, Bijay, 2006-02-14
catalystActivity	[CatalystActivity:173601] UDP-glucose 6-dehydrogenase activity of 6xUGDH [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:173596] Jassal, Bijay, 2006-02-14
crossReference	[DatabaseIdentifier:9912873] RHEA:23597
edited	[InstanceEdit:173596] Jassal, Bijay, 2006-02-14
input	[SimpleEntity:29410] UDP-Glc [cytosol] [SimpleEntity:29360] NAD+ [cytosol] [SimpleEntity:29360] NAD+ [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9913491] D'Eustachio, Peter, 2024-06-14
literatureReference	[LiteratureReference:266226] Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations
modified	[InstanceEdit:174378] Jassal, Bijay, 2006-02-17 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:266244] Jassal, Bijay, 2008-04-29 [InstanceEdit:353652] Jassal, Bijay, 2008-06-13 [InstanceEdit:389952] Jassal, Bijay, 2009-01-21 [InstanceEdit:762750] Jassal, Bijay, 2010-05-20 [InstanceEdit:762751] Jassal, Bijay, 2010-05-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9912893] D'Eustachio, Peter, 2024-06-10 [InstanceEdit:9913490] D'Eustachio, Peter, 2024-06-14 [InstanceEdit:9916040] D'Eustachio, Peter, 2024-07-19
name	UDP-glucose is oxidised to UDP-glucuronate H2O + 2 NAD(+) + UDP-alpha-D-glucose => 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate
output	[SimpleEntity:158601] UDP-GlcA [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:70286] UTP + D-glucose 1-phosphate => pyrophosphate + UDP-glucose [Homo sapiens] [Reaction:71590] glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL] [Homo sapiens] [Reaction:9638127] PGM1:Mg2+ isomerises G6P to G1P [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2010-06-15
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54 [InstanceEdit:9916041] Hill, David P, 2024-07-19
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360699] R-HSA-173597.3
structureModified	[InstanceEdit:9912893] D'Eustachio, Peter, 2024-06-10
summation	[Summation:179286] UDP-glucose dehydrogenase (UGDH) catalyzes the conversion of...
(hasEvent)	[Pathway:173599] Formation of the active cofactor, UDP-glucuronate [Homo sapiens]
(precedingEvent)	[Reaction:174368] SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen [Homo sapiens] [Polymerisation:2160851] HAS1,2,3 mediate the polymerization and export of HA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9791580] Update Tracker - [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate - v28:[addOutput] [_UpdateTracker:9791916] Update Tracker - [Reaction:173597] UDP-glucose is oxidised to UDP-glucuronate - v25:[addLiteratureReference, modifyText]
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