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Details on Person I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)

Class:Id	Reaction:173512
_displayName	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
_doRelease	TRUE
_timestamp	2016-12-01 00:31:43
authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35
edited	[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35 [InstanceEdit:2187413] Jassal, B, 2012-04-10
goBiologicalProcess	[GO_BiologicalProcess:23765] negative regulation of transforming growth factor beta receptor signaling pathway
input	[Complex:170841] TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:173478] SMAD7 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:178160] Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling [LiteratureReference:178152] The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
modified	[InstanceEdit:176038] Jassal, B, 2006-03-01 09:49:08 [InstanceEdit:177100] Jassal, B, 2006-03-22 11:41:32 [InstanceEdit:177252] Jassal, B, 2006-03-24 14:33:15 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:178153] Jassal, B, 2006-04-18 13:29:09 [InstanceEdit:178242] Jassal, B, 2006-04-18 14:30:44 [InstanceEdit:191098] Jassal, B, 2007-01-18 10:50:08 [InstanceEdit:1530027] Orlic-Milacic, Marija, 2011-08-25 [InstanceEdit:2167891] Orlic-Milacic, M, 2012-03-22 [InstanceEdit:2187532] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197658] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2197660] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250318] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:8949915] D'Eustachio, Peter, 2016-12-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
output	[Complex:173476] TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:2106591] WWTR1:SMAD stimulates transcription of SMAD7 [Homo sapiens] [Reaction:9736970] WWTR1:p-2S-SMAD2,3:SMAD4 binds SMAD7 gene promoter [Homo sapiens] [Reaction:5252001] ATP1B4 binds SNW1 [Homo sapiens]
releaseDate	2006-04-24
reviewed	[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12 [InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359362] R-HSA-173512.3
summation	[Summation:173491] I-SMADs (SMAD6 and SMAD7) reside in the nucleus presumably t...
(hasEvent)	[Pathway:2173788] Downregulation of TGF-beta receptor signaling [Homo sapiens]
(precedingEvent)	[Reaction:178189] SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788586] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v41:[add_removeInput] [_UpdateTracker:9789418] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v38:[modifyText] [_UpdateTracker:9792518] Update Tracker - [Reaction:173512] I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) - v20:[removeCatalystActivity]
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