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Details on Person The SMAD2/3:SMAD4 complex transfers to the nucleus

Class:Id	BlackBoxEvent:173488
_displayName	The SMAD2/3:SMAD4 complex transfers to the nucleus
_doRelease	TRUE
_timestamp	2022-05-09 21:49:13
authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35
edited	[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input	[DefinedSet:171175] p-2S-SMAD2,3:SMAD4 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:173516] The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation [LiteratureReference:178148] Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner [LiteratureReference:178143] An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity [LiteratureReference:208381] Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads [LiteratureReference:2584304] Coupling of dephosphorylation and nuclear export of Smads in TGF-beta signaling [LiteratureReference:2584303] Nucleocytoplasmic shuttling of Smad proteins
modified	[InstanceEdit:173517] Jassal, B, 2006-02-10 14:14:33 [InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50 [InstanceEdit:176038] Jassal, B, 2006-03-01 09:49:08 [InstanceEdit:177252] Jassal, B, 2006-03-24 14:33:15 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:178141] Jassal, B, 2006-04-18 13:28:06 [InstanceEdit:178236] Jassal, B, 2006-04-18 14:30:18 [InstanceEdit:1530034] Orlic-Milacic, Marija, 2011-08-25 [InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2197660] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2197822] Orlic-Milacic, M, 2012-04-16 [InstanceEdit:2250375] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:2584310] May, B, 2012-11-14 [InstanceEdit:2584313] May, B, 2012-11-14 [InstanceEdit:8858361] Jupe, Steve, 2016-02-18 [InstanceEdit:9731423] Orlic-Milacic, Marija, 2021-05-20 [InstanceEdit:9732722] Orlic-Milacic, Marija, 2021-05-31 [InstanceEdit:9773673] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The SMAD2/3:SMAD4 complex transfers to the nucleus
output	[DefinedSet:173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens] [Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR [Homo sapiens] [Reaction:1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor [Homo sapiens] [Reaction:1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor [Homo sapiens]
regulatedBy	[NegativeRegulation:9732720] Negative regulation by 'p-T,Y MAPK dimers [cytosol]'
releaseDate	2006-04-24
reviewed	[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12 [InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360580] R-HSA-173488.5
summation	[Summation:176008] The phosphorylated R-SMAD:CO-SMAD complex rapidly translocat...
(hasEvent)	[Pathway:1181150] Signaling by NODAL [Homo sapiens] [Pathway:1502540] Signaling by Activin [Homo sapiens] [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(precedingEvent)	[Reaction:173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling [Homo sapiens] [BlackBoxEvent:173545] Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling [Homo sapiens] [Pathway:177106] I-SMAD recruits type I receptor phosphatase and ubiquitin ligases to mediate receptor downregulation [Homo sapiens] [Reaction:870538] TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus [Homo sapiens] [Reaction:1225919] Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element [Homo sapiens] [Reaction:1535903] Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements [Homo sapiens] [Reaction:2127257] SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 [Homo sapiens] [Reaction:2176475] Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 [Homo sapiens] [Reaction:2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer [Homo sapiens] [Reaction:2186643] MEN1 binds SMAD2/3:SMAD4 heterotrimer [Homo sapiens] List all 32 refering instances
(updatedInstance)	[_UpdateTracker:9775750] Update Tracker - [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - v78:[addRegulator, modifyText] [_UpdateTracker:9788231] Update Tracker - [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - v43:[addLiteratureReference] [_UpdateTracker:9788639] Update Tracker - [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - v41:[modifyText] [_UpdateTracker:9789229] Update Tracker - [BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - v38:[modifyText]
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