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Details on Person (Frs2)C3G stimulates nucleotide exchange on Rap1

Class:Id	Reaction:170979
_displayName	(Frs2)C3G stimulates nucleotide exchange on Rap1
_doRelease	TRUE
_timestamp	2018-06-05 18:30:05
authored	[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006-10-10
catalystActivity	[CatalystActivity:170980] guanyl-nucleotide exchange factor activity of Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane]
compartment	[Compartment:17940] endosome
created	[InstanceEdit:170970] Jassal, B, 2006-01-25 09:53:37
edited	[InstanceEdit:188340] Jassal, Bijay, 2006-10-10
inferredFrom	[Reaction:182053] C3G stimulates nucleotide exchange on Rap1 [Rattus norvegicus]
input	[Complex:190077] RAP1:GDP [endosome membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:182068] Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
modified	[InstanceEdit:182105] Jassal, Bijay, 2006-07-06 [InstanceEdit:187638] Jassal, B, 2006-09-21 12:50:35 [InstanceEdit:187777] Jassal, B, 2006-09-22 13:26:43 [InstanceEdit:188337] Jassal, Bijay, 2006-10-10 [InstanceEdit:188431] Gopinathrao, G, 2006-10-12 14:53:00 [InstanceEdit:188617] Jassal, B, 2006-10-19 08:11:52 [InstanceEdit:190076] Jassal, B, 2006-12-14 13:53:55 [InstanceEdit:196906] Gopinathrao, G, 2007-04-25 14:54:44 [InstanceEdit:204297] Jassal, Bijay, 2007-11-28 [InstanceEdit:1806830] Jassal, Bijay, 2011-10-24 [InstanceEdit:1972364] Jassal, B, 2011-11-04 [InstanceEdit:9610173] Rothfels, Karen, 2018-06-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	(Frs2)C3G stimulates nucleotide exchange on Rap1
output	[Complex:190069] RAP1:GTP [endosome membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:170978] p-FRS2:CRKL binds C3G [Homo sapiens] [Reaction:170975] p-FRS2 binds CRKL [Homo sapiens]
releaseDate	2007-12-11
reviewed	[InstanceEdit:202668] Greene, LA, 2007-11-08 15:39:37
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360570] R-HSA-170979.3
summation	[Summation:187780] Rap1 is a small G protein, necessary for prolonged ERK activ...
(hasEvent)	[Pathway:170968] Frs2-mediated activation [Homo sapiens]
(precedingEvent)	[Reaction:170965] (Frs2)Rap1-GTP binds to and activates B-Raf [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779245] Update Tracker - [Reaction:170979] (Frs2)C3G stimulates nucleotide exchange on Rap1 - v66:[addLiteratureReference, add_removeInput, add_removeOutput]
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