Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Phosphorylated SMAD2/3 dissociates from TGFBR

Class:IdReaction:170850
_displayNamePhosphorylated SMAD2/3 dissociates from TGFBR
_doReleaseTRUE
_timestamp2012-05-16 02:12:19
authored[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment[Compartment:17941] early endosome
created[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
edited[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
input[Complex:171180] TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] [Homo sapiens]
literatureReference[LiteratureReference:177257] MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling
[LiteratureReference:175954] TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
[LiteratureReference:177255] Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
[LiteratureReference:208376] Structural basis of heteromeric smad protein assembly in TGF-beta signaling
modified[InstanceEdit:171185] Jassal, B, 2006-01-30 14:50:44
[InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35
[InstanceEdit:175942] Jassal, B, 2006-02-27 10:52:38
[InstanceEdit:175950] Jassal, B, 2006-02-27 11:21:52
[InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50
[InstanceEdit:176038] Jassal, B, 2006-03-01 09:49:08
[InstanceEdit:177252] Jassal, B, 2006-03-24 14:33:15
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:178242] Jassal, B, 2006-04-18 14:30:44
[InstanceEdit:1530031] Orlic-Milacic, Marija, 2011-08-25
[InstanceEdit:2190599] Orlic-Milacic, M, 2012-04-10
[InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2197660] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2250335] Orlic-Milacic, M, 2012-05-15
[InstanceEdit:2251526] Orlic-Milacic, M, 2012-05-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePhosphorylated SMAD2/3 dissociates from TGFBR
output[Complex:171173] TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] [Homo sapiens]
[DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2006-04-24
reviewed[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12
[InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360163] R-HSA-170850.2
summation[Summation:176005] Upon phosphorylation of the R-SMAD (SMAD2/3), the conformati...
(hasEvent)[Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens]
(precedingEvent)[Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens]
[Reaction:2187355] PMEPA1 sequesters phosphorylated SMAD2/3 [Homo sapiens]
[Reaction:2187405] MTMR4 binds phosphorylated SMAD2/3 [Homo sapiens]
[Reaction:9846552] GOCAM Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787285] Update Tracker - [Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR - v46:[modifyText]
[_UpdateTracker:9788709] Update Tracker - [Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR - v41:[addLiteratureReference, modifyText]
[_UpdateTracker:9789520] Update Tracker - [Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR - v38:[modifyText]
[_UpdateTracker:9792190] Update Tracker - [Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR - v23:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by Phosphorylated SMAD2/3 dissociates from TGFBR (170850)
Follow Reactome