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Details on Person Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4

Class:Id	Reaction:170847
_displayName	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
_doRelease	TRUE
_timestamp	2022-05-09 21:48:39
authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
edited	[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52 [InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
input	[EntityWithAccessionedSequence:170862] SMAD4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:170862] SMAD4 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:170862] SMAD4 [cytosol] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens] [DefinedSet:171182] p-2S-SMAD2,3 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:175954] TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 [LiteratureReference:1225903] Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors [LiteratureReference:202606] Structural basis of Smad1 activation by receptor kinase phosphorylation [LiteratureReference:208376] Structural basis of heteromeric smad protein assembly in TGF-beta signaling [LiteratureReference:208162] Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling. [LiteratureReference:3009206] Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling
modified	[InstanceEdit:171185] Jassal, B, 2006-01-30 14:50:44 [InstanceEdit:173513] Jassal, B, 2006-02-10 14:02:35 [InstanceEdit:175950] Jassal, B, 2006-02-27 11:21:52 [InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50 [InstanceEdit:176038] Jassal, B, 2006-03-01 09:49:08 [InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11 [InstanceEdit:178242] Jassal, B, 2006-04-18 14:30:44 [InstanceEdit:1181350] May, B, 2011-02-04 [InstanceEdit:1225868] May, B, 2011-03-03 [InstanceEdit:1530030] Orlic-Milacic, Marija, 2011-08-25 [InstanceEdit:2190599] Orlic-Milacic, M, 2012-04-10 [InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2197660] Orlic-Milacic, M, 2012-04-13 [InstanceEdit:2250334] Orlic-Milacic, M, 2012-05-15 [InstanceEdit:2251525] Orlic-Milacic, M, 2012-05-16 [InstanceEdit:2470838] May, B, 2012-09-19 [InstanceEdit:2584310] May, B, 2012-11-14 [InstanceEdit:2584313] May, B, 2012-11-14 [InstanceEdit:3009209] Orlic-Milacic, M, 2013-02-04 [InstanceEdit:3009229] Orlic-Milacic, M, 2013-02-04 [InstanceEdit:8858361] Jupe, Steve, 2016-02-18 [InstanceEdit:9628440] Orlic-Milacic, Marija, 2018-11-08 [InstanceEdit:9736370] Shamovsky, Veronica, 2021-07-07 [InstanceEdit:9751111] Orlic-Milacic, Marija, 2021-08-18 [InstanceEdit:9751155] Shamovsky, Veronica, 2021-08-18 [InstanceEdit:9754418] Orlic-Milacic, Marija, 2021-09-24 [InstanceEdit:9773749] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9773751] Orlic-Milacic, Marija, 2022-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
negativePrecedingEvent	[NegativePrecedingEvent:9754412] Futile Cycle: USP9X (FAM) deubiquitinates SMAD4
output	[DefinedSet:171175] p-2S-SMAD2,3:SMAD4 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:170850] Phosphorylated SMAD2/3 dissociates from TGFBR [Homo sapiens] [Reaction:170868] Activated type I receptor phosphorylates SMAD2/3 directly [Homo sapiens] [Reaction:1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor [Homo sapiens] [Reaction:1181156] Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL [Homo sapiens] [Reaction:1225894] Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL [Homo sapiens] [Reaction:1549526] Phosphorylation of SMAD2,3 by Activin:Activin Receptor [Homo sapiens] [Reaction:1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin [Homo sapiens] [Reaction:2470508] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin [Homo sapiens]
releaseDate	2006-04-24
reviewed	[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12 [InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:2186595] Orlic-Milacic, M, 2012-04-04 [InstanceEdit:3009218] Orlic-Milacic, M, 2013-02-04
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359289] R-HSA-170847.7
summation	[Summation:176014] The phosphorylated C-terminal tail of R-SMAD induces a confo...
(hasEvent)	[Pathway:1181150] Signaling by NODAL [Homo sapiens] [Pathway:1502540] Signaling by Activin [Homo sapiens] [Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens] [Pathway:2173796] SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [Homo sapiens]
(normalReaction)	[FailedReaction:3311014] SMAD4 MH2 Domain Mutants do not bind phosphorylated SMAD2 and SMAD3 [Homo sapiens] [FailedReaction:3315483] Phosphorylated SMAD2/3 MH2 Domain Mutants do not bind SMAD4 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens] [Reaction:2031355] WWTR1 binds SMAD2/3:SMAD4 heterotrimer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775664] Update Tracker - [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - v78:[modifyText] [_UpdateTracker:9788018] Update Tracker - [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - v44:[addLiteratureReference, modifyText] [_UpdateTracker:9788233] Update Tracker - [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - v43:[addLiteratureReference] [_UpdateTracker:9788685] Update Tracker - [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - v41:[addLiteratureReference, modifyText] [_UpdateTracker:9789181] Update Tracker - [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - v38:[addLiteratureReference, modifyText] [_UpdateTracker:9789860] Update Tracker - [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - v37:[addLiteratureReference] [_UpdateTracker:9792168] Update Tracker - [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 - v23:[modifyText]
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