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Details on Person TGFBR2 recruits TGFBR1

Class:IdReaction:170846
_displayNameTGFBR2 recruits TGFBR1
_doReleaseTRUE
_timestamp2023-08-21 15:33:56
authored[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
edited[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
[InstanceEdit:2187413] Jassal, B, 2012-04-10
input[Complex:170865] Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] [Homo sapiens]
[Complex:2187279] TGFBR1:FKBP1A [plasma membrane] [Homo sapiens]
[Complex:2187279] TGFBR1:FKBP1A [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9842182] Orlic-Milacic, Marija, 2023-08-21
literatureReference[LiteratureReference:177254] TGF beta signals through a heteromeric protein kinase receptor complex
[LiteratureReference:177258] The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand
[LiteratureReference:177261] Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor
[LiteratureReference:2187282] Mechanism of TGFbeta receptor inhibition by FKBP12
[LiteratureReference:3009231] Monomeric type I and type III transforming growth factor-? receptors and their dimerization revealed by single-molecule imaging
modified[InstanceEdit:174853] Jassal, B, 2006-02-21 10:33:58
[InstanceEdit:175942] Jassal, B, 2006-02-27 10:52:38
[InstanceEdit:175950] Jassal, B, 2006-02-27 11:21:52
[InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50
[InstanceEdit:177252] Jassal, B, 2006-03-24 14:33:15
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:178242] Jassal, B, 2006-04-18 14:30:44
[InstanceEdit:1530043] Orlic-Milacic, Marija, 2011-08-25
[InstanceEdit:2187283] Orlic-Milacic, M, 2012-04-08
[InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2197660] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2197821] Orlic-Milacic, M, 2012-04-16
[InstanceEdit:2250378] Orlic-Milacic, M, 2012-05-15
[InstanceEdit:2251530] Orlic-Milacic, M, 2012-05-16
[InstanceEdit:2262784] Orlic-Milacic, M, 2012-05-21
[InstanceEdit:3009235] Orlic-Milacic, M, 2013-02-04
[InstanceEdit:3009236] Orlic-Milacic, M, 2013-02-04
[InstanceEdit:3656385] Orlic-Milacic, M, 2013-06-04
[InstanceEdit:9675161] D'Eustachio, Peter, 2020-01-31
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05
[InstanceEdit:9840921] Tiwari, Krishna, 2023-08-01
[InstanceEdit:9842183] Orlic-Milacic, Marija, 2023-08-21
nameTGFBR2 recruits TGFBR1
Type II receptor recruits type I receptor
output[Complex:170840] TGFB1:TGFBR2:TGFBR1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:2026007] FKBP1A [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:2026007] FKBP1A [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[PositiveRegulation:9839330] Positive regulation by 'TGFB1_2:TGFBR3:TGFBR2 [plasma membrane]'
regulationReference[RegulationReference:9840922] Positive regulation by 'TGFB1_2:TGFBR3:TGFBR2 [plasma membrane]' Betaglycan presents ligand to the TGF beta signaling receptor
releaseDate2006-04-24
reviewed[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12
[InstanceEdit:2250308] Huang, Tao, 2012-05-14
[InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
reviewStatus[ReviewStatus:9821385] four stars
revised[InstanceEdit:2186595] Orlic-Milacic, M, 2012-04-04
[InstanceEdit:3009235] Orlic-Milacic, M, 2013-02-04
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359963] R-HSA-170846.4
structureModified[InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05
summation[Summation:176012] The protein complex of dimeric TGF-beta-1 with the type II r...
(hasEvent)[Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens]
(normalReaction)[FailedReaction:3656382] TGFBR2 does not recruit TGFBR1 LBD Mutants [Homo sapiens]
(precedingEvent)[Reaction:170843] TGFBR2 phosphorylates TGFBR1 [Homo sapiens]
[Reaction:2127609] STRAP binds unphosphorylated TGF-beta receptor complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9777124] Update Tracker - [Reaction:170846] TGFBR2 recruits TGFBR1 - v72:[removeCatalystActivity]
[_UpdateTracker:9787908] Update Tracker - [Reaction:170846] TGFBR2 recruits TGFBR1 - v44:[addLiteratureReference, modifyText]
[_UpdateTracker:9788531] Update Tracker - [Reaction:170846] TGFBR2 recruits TGFBR1 - v41:[addLiteratureReference, addOutput, add_removeInput, modifyText]
[_UpdateTracker:9789241] Update Tracker - [Reaction:170846] TGFBR2 recruits TGFBR1 - v38:[modifyText]
[_UpdateTracker:9842229] Update Tracker - [Reaction:170846] TGFBR2 recruits TGFBR1 - v86:[addRegulator, modifyText]
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