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Details on Person TGFBR2 phosphorylates TGFBR1

Class:IdReaction:170843
_displayNameTGFBR2 phosphorylates TGFBR1
_doReleaseTRUE
_timestamp2013-08-14 20:29:25
authored[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
catalystActivity[CatalystActivity:170856] transforming growth factor beta receptor activity, type II of TGFB1:TGFBR2:TGFBR1 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
edited[InstanceEdit:170836] Jassal, B, 2006-01-18 10:19:52
input[Complex:170840] TGFB1:TGFBR2:TGFBR1 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
literatureReference[LiteratureReference:175963] Mechanism of activation of the TGF-beta receptor
[LiteratureReference:175965] Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses
[LiteratureReference:4127454] The type I TGF-beta receptor is covalently modified and regulated by sumoylation
modified[InstanceEdit:175950] Jassal, B, 2006-02-27 11:21:52
[InstanceEdit:176006] Jassal, B, 2006-02-28 10:02:50
[InstanceEdit:177473] Gopinathrao, G, 2006-03-30 18:00:11
[InstanceEdit:178162] Jassal, B, 2006-04-18 13:31:36
[InstanceEdit:178242] Jassal, B, 2006-04-18 14:30:44
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1484110] Orlic-Milacic, Marija, 2011-08-12
[InstanceEdit:1530042] Orlic-Milacic, Marija, 2011-08-25
[InstanceEdit:2197659] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2197660] Orlic-Milacic, M, 2012-04-13
[InstanceEdit:2250377] Orlic-Milacic, M, 2012-05-15
[InstanceEdit:2251529] Orlic-Milacic, M, 2012-05-16
[InstanceEdit:3656511] Orlic-Milacic, M, 2013-06-05
[InstanceEdit:4127457] Orlic-Milacic, M, 2013-08-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameTGFBR2 phosphorylates TGFBR1
Type II receptor phosphorylates type I receptor
output[Complex:170841] TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2006-04-24
reviewed[InstanceEdit:178196] Heldin, CH, 2006-04-18 14:26:12
[InstanceEdit:2250308] Huang, Tao, 2012-05-14
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359661] R-HSA-170843.2
summation[Summation:176016] Formation of the hetero-tetrameric TGF-beta-1 receptor compl...
(hasEvent)[Pathway:2173789] TGF-beta receptor signaling activates SMADs [Homo sapiens]
(normalReaction)[FailedReaction:3645780] TGFBR2 KD mutants do not phosphorylate TGFBR1 [Homo sapiens]
(precedingEvent)[Reaction:170835] An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 [Homo sapiens]
[Reaction:2127562] STRAP binds phosphorylated TGF-beta receptor complex [Homo sapiens]
(updatedInstance)[_UpdateTracker:9787015] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v46:[addLiteratureReference]
[_UpdateTracker:9788519] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v41:[modifyText]
[_UpdateTracker:9789304] Update Tracker - [Reaction:170843] TGFBR2 phosphorylates TGFBR1 - v38:[modifyText]
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