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Details on Person nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)

Class:IdReaction:170810
_displayNamenucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
_doReleaseTRUE
_timestamp2025-08-13 19:24:06
catalystActivity[CatalystActivity:9954132] glucose sensor activity of GCK1:GCKR complex [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:170815] D'Eustachio, P, 2006-01-17 15:36:38
edited[InstanceEdit:174827] D'Eustachio, P, 2006-02-20 18:39:56
input[Complex:170804] GCK1:GCKR complex [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9954135] D'Eustachio, Peter, 2025-06-06
literatureReference[LiteratureReference:170794] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
modified[InstanceEdit:174828] D'Eustachio, P, 2006-02-20 18:48:02
[InstanceEdit:177299] D'Eustachio, P, 2006-03-27 19:03:40
[InstanceEdit:199720] D'Eustachio, P, 2007-07-11 20:28:53
[InstanceEdit:450085] D'Eustachio, P, 2009-12-11
[InstanceEdit:467366] D'Eustachio, P, 2010-01-24
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9954133] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9954136] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9963234] D'Eustachio, Peter, 2025-08-13
namenucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
Dissociation of the nucleoplasmic GCK1:GCKR complex
output[EntityWithAccessionedSequence:450102] GCK [nucleoplasm] [Homo sapiens]
[EntityWithAccessionedSequence:170805] GCKR [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
regulatedBy[PositiveRegulation:170807] Positive regulation by 'Glc [nucleoplasm]'
releaseDate2005-06-13
reviewed[InstanceEdit:9963235] Hill, David P, 2025-08-13
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361521] R-HSA-170810.5
structureModified[InstanceEdit:9954133] D'Eustachio, Peter, 2025-06-06
summation[Summation:170814] In the presence of high glucose concentrations, the complex ...
(hasEvent)[Pathway:170822] Regulation of Glucokinase by Glucokinase Regulatory Protein [Homo sapiens]
(precedingEvent)[BlackBoxEvent:170825] NPC exports GCK1 from nucleus [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791048] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) - v32:[add_removeOutput, modifyText]
[_UpdateTracker:9792382] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GKRP complex => glucokinase (GCK1) + glucokinase regulatory protein (GKRP) - v22:[addLiteratureReference]
[_UpdateTracker:9964694] Update Tracker - [Reaction:170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) - v94:[modifyText, removeCatalystActivity]
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No pathways have been reviewed or authored by nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) (170810)
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