Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person NPC transports GCK1:GCKR from cytosol to nucleoplasm

Class:IdBlackBoxEvent:170796
_displayNameNPC transports GCK1:GCKR from cytosol to nucleoplasm
_doReleaseTRUE
_timestamp2025-11-11 20:11:01
catalystActivity[CatalystActivity:450099] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope]
catalystActivityReference[CatalystActivityReference:9643944] structural constituent of nuclear pore activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
compartment[Compartment:13231] nuclear envelope
created[InstanceEdit:170815] D'Eustachio, P, 2006-01-17 15:36:38
edited[InstanceEdit:174827] D'Eustachio, P, 2006-02-20 18:39:56
goBiologicalProcess[GO_BiologicalProcess:11054] protein import into nucleus
input[Complex:170827] GCK1:GCKR complex [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9965335] D'Eustachio, Peter, 2025-08-28
literatureReference[LiteratureReference:170794] Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase
modified[InstanceEdit:174828] D'Eustachio, P, 2006-02-20 18:48:02
[InstanceEdit:177299] D'Eustachio, P, 2006-03-27 19:03:40
[InstanceEdit:450085] D'Eustachio, P, 2009-12-11
[InstanceEdit:467366] D'Eustachio, P, 2010-01-24
[InstanceEdit:5661406] Jassal, Bijay, 2015-01-12
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9643047] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9933517] Stephan, Ralf, 2025-01-01
[InstanceEdit:9954133] D'Eustachio, Peter, 2025-06-06
[InstanceEdit:9965334] D'Eustachio, Peter, 2025-08-28
[InstanceEdit:9965336] D'Eustachio, Peter, 2025-08-28
[InstanceEdit:9965338] D'Eustachio, Peter, 2025-08-28
[InstanceEdit:9971781] Matthews, Lisa, 2025-11-11
[InstanceEdit:9971785] Matthews, Lisa, 2025-11-11
nameNPC transports GCK1:GCKR from cytosol to nucleoplasm
Transport of glucokinase (GCK1):GCKR complex to the nucleus
output[Complex:170804] GCK1:GCKR complex [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
releaseDate2006-04-24
reviewed[InstanceEdit:9965339] Hill, David P, 2025-08-28
[InstanceEdit:9971784] D'Eustachio, Peter, 2025-11-11
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:450087] D'Eustachio, P, 2009-12-11
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361705] R-HSA-170796.7
structureModified[InstanceEdit:9965334] D'Eustachio, Peter, 2025-08-28
[InstanceEdit:9971781] Matthews, Lisa, 2025-11-11
summation[Summation:170802] The complex of glucokinase (GCK1) and glucokinase regulatory...
(hasEvent)[Pathway:170822] Regulation of Glucokinase by Glucokinase Regulatory Protein [Homo sapiens]
(normalReaction)[FailedReaction:5661474] Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm [Homo sapiens]
(precedingEvent)[Reaction:170810] nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9791152] Update Tracker - [Reaction:170796] NPC transports GCK1:GKRP from cytosol to nucleoplasm - v32:[addCatalystActivity, modifyText, removeRegulator]
[_UpdateTracker:9964633] Update Tracker - [BlackBoxEvent:170796] NPC transports GCK1:GCKR from cytosol to nucleoplasm - v94:[modifyText]
[Change default viewing format]
No pathways have been reviewed or authored by NPC transports GCK1:GCKR from cytosol to nucleoplasm (170796)
Follow Reactome