Query author contributions in Reactome
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Details on Person This HIV-1 event was inferred from the corresponding human R...
| Class:Id | Summation:170748 |
|---|---|
| _displayName | This HIV-1 event was inferred from the corresponding human R... |
| _timestamp | 2006-01-15 13:56:17 |
| created | [InstanceEdit:170768] Matthews, L, 2006-01-15 13:04:15 |
| literatureReference | [LiteratureReference:170758] NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation |
| modified | [InstanceEdit:170772] Matthews, L, 2006-01-15 13:56:07 |
| text | This HIV-1 event was inferred from the corresponding human RNA Pol II transcription event. NELF complex is a ~ 300 kDa multiprotein complex composed of 5 peptides (A - E): ~66,61,59,58 and 46 kDa (Yamaguchi et al 1999). All these peptides are required for NELF-mediated inhibition of Pol II elongation. NELF complex has been reported to bind to the pre-formed DSIF:RNA Pol II complex that may act as a scaffold for its binding. NELF-A is suspected to be involved in Wolf-Hirschhorn syndrome. Binding of DSIF:NELF to RNA Pol II CTD results in abortive termination of early elongation steps by the growing transcripts. |
| (summation) | [Reaction:167085] Formation of DSIF:NELF:HIV-1 early elongation complex [Homo sapiens] |
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No pathways have been reviewed or authored by This HIV-1 event was inferred from the corresponding human R... (170748)
