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Details on Person Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex

Class:Id	Reaction:170706
_displayName	Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
_doRelease	TRUE
_timestamp	2016-11-10 00:56:02
authored	[InstanceEdit:165064] Matthews, L, Rice, AP, 2005-07-27 00:00:00
catalystActivity	[CatalystActivity:170708] RNA polymerase II CTD heptapeptide repeat kinase activity of Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:170702] Matthews, L, 2006-01-13 13:37:22
disease	[Disease:1660559] Human immunodeficiency virus infectious disease
input	[Complex:167182] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] [Homo sapiens] [SimpleEntity:29358] ATP [nucleoplasm]
literatureReference	[LiteratureReference:170711] Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element
modified	[InstanceEdit:170768] Matthews, L, 2006-01-15 13:04:15 [InstanceEdit:3632906] Gillespie, ME, 2013-05-28 [InstanceEdit:5621512] Matthews, Lisa, 2014-08-29 [InstanceEdit:6787529] D'Eustachio, Peter, 2015-07-14 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
output	[Complex:170707] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] [Homo sapiens] [SimpleEntity:113582] ADP [nucleoplasm]
precedingEvent	[Reaction:167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex [Homo sapiens] [Reaction:167085] Formation of DSIF:NELF:HIV-1 early elongation complex [Homo sapiens] [Reaction:112430] Formation of P-TEFb complex [Homo sapiens]
relatedSpecies	[Species:164493] Human immunodeficiency virus 1
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360027] R-HSA-170706.4
summation	[Summation:170752] Phosphorylation of the RD subunit of NEFL by P-TEFb(Cyclin T...
(hasEvent)	[Pathway:167200] Formation of HIV-1 elongation complex containing HIV-1 Tat [Homo sapiens]
(precedingEvent)	[Reaction:170704] Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784355] Update Tracker - [Reaction:170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex - v54:[addLiteratureReference]
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