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Details on Person During interphase, CDC25C, phosphorylated on serine residue ...
| Class:Id | Summation:170241 |
|---|---|
| _displayName | During interphase, CDC25C, phosphorylated on serine residue ... |
| _timestamp | 2017-03-13 20:05:25 |
| created | [InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46 |
| literatureReference | [LiteratureReference:170235] Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C |
| modified | [InstanceEdit:2026128] Orlic-Milacic, M, 2011-12-22 [InstanceEdit:8981702] Orlic-Milacic, Marija, 2017-03-13 [InstanceEdit:8981707] Orlic-Milacic, Marija, 2017-03-13 |
| text | During interphase, CDC25C, phosphorylated on serine residue 216, is associated with 14-3-3 proteins, preventing nuclear import. At the onset of mitosis, dephosphorylation of S216 of Cdc25C and dissociation of 14-3-3, with phosphorylation of CDC25C on S198 by activated PLK1 promotes nuclear import (Takizawa and Morgan 2000, Toyoshima-Morimoto et al. 2002, Bonnet et al. 2008). Activating CDC25C phosphorylation and nuclear translocation may further be enhanced by activated CCNB:CDK1 complexes (Bonnet et al. 2008). |
| (summation) | [Reaction:170149] Translocation of active Cdc25C to the nucleus [Homo sapiens] |
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No pathways have been reviewed or authored by During interphase, CDC25C, phosphorylated on serine residue ... (170241)
