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Details on Person Translocation of Cdc25 to the nucleus

Class:Id	Reaction:170159
_displayName	Translocation of Cdc25 to the nucleus
_doRelease	TRUE
_timestamp	2022-02-08 21:59:32
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:170148] Matthews, L, 2005-12-23 13:53:48
input	[DefinedSet:170108] CDC25 [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:170222] Cdc25A localisation and shuttling: characterisation of sequences mediating nuclear export and import [LiteratureReference:170197] Characterisation of Cdc25B localisation and nuclear export during the cell cycle and in response to stress [LiteratureReference:75017] Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.
modified	[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46 [InstanceEdit:180189] Matthews, L, 2006-05-16 20:52:42 [InstanceEdit:186978] Matthews, L, 2006-09-05 23:26:55 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:8981825] Orlic-Milacic, Marija, 2017-03-14 [InstanceEdit:9764055] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Translocation of Cdc25 to the nucleus
negativePrecedingEvent	[NegativePrecedingEvent:9764051] Futile Cycle: Translocation of Cdc25B to the cytoplasm
output	[DefinedSet:69261] CDC25 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:156678] Activation of Cdc25C [Homo sapiens] [BlackBoxEvent:6798268] TP53 and E2F4 inhibit CDC25C expression [Homo sapiens]
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360079] R-HSA-170159.5
summation	[Summation:170202] The localization of the Cdc25A, B and C proteins is dynamic ...
(hasEvent)	[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(precedingEvent)	[Reaction:170120] Translocation of Cdc25B to the cytoplasm [Homo sapiens] [Reaction:170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases [Homo sapiens] [Reaction:170158] CDC25A dephosphorylates CCNA:CDK1 [Homo sapiens] [Reaction:9929935] CCNA:CDK1 phosphorylates CDC25B [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9781270] Update Tracker - [Reaction:170159] Translocation of Cdc25 to the nucleus - v61:[add_removeOutput]
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