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Details on Person CDC25A dephosphorylates CCNA:CDK1

Class:IdReaction:170158
_displayNameCDC25A dephosphorylates CCNA:CDK1
_doReleaseTRUE
_timestamp2025-01-22 15:37:13
catalystActivity[CatalystActivity:69198] phosphoprotein phosphatase activity of CDC25A [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:170148] Matthews, L, 2005-12-23 13:53:48
edited[InstanceEdit:9929531] Orlic-Milacic, Marija, 2024-11-26
figure[Figure:72794] /figures/cyclinab_cdk1_dp.jpg
input[CandidateSet:170147] CCNA:p-T14,Y15,T161-CDK1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113518] H2O [nucleoplasm]
[SimpleEntity:113518] H2O [nucleoplasm]
literatureReference[LiteratureReference:8981853] Human Cdc25A phosphatase has a non-redundant function in G2 phase by activating Cyclin A-dependent kinases
modified[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46
[InstanceEdit:170446] Matthews, L, 2006-01-06 17:29:05
[InstanceEdit:170643] Matthews, L, 2006-01-09 10:00:42
[InstanceEdit:2026129] Orlic-Milacic, M, 2011-12-22
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8981869] Orlic-Milacic, Marija, 2017-03-14
[InstanceEdit:9764023] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9764055] Orlic-Milacic, Marija, 2022-02-08
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929480] Orlic-Milacic, Marija, 2024-11-26
[InstanceEdit:9929531] Orlic-Milacic, Marija, 2024-11-26
[InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18
[InstanceEdit:9936323] Orlic-Milacic, Marija, 2025-01-22
nameCDC25A dephosphorylates CCNA:CDK1
Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes
output[CandidateSet:170146] CCNA:p-T161-CDK1 [nucleoplasm] [Homo sapiens]
[SimpleEntity:113550] Pi [nucleoplasm]
[SimpleEntity:113550] Pi [nucleoplasm]
precedingEvent
releaseDate2005-04-11
reviewed[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358602] R-HSA-170158.6
summation[Summation:170186] Activation of the cyclin A:Cdc2 complexes at mitosis require...
(hasEvent)[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(precedingEvent)[Reaction:4088024] CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1 [Homo sapiens]
[Reaction:9929514] CDK1 phosphorylates CCNA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781098] Update Tracker - [Reaction:170158] Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes - v61:[addLiteratureReference, add_removeCatalystActivity, modifyText]
[_UpdateTracker:9939822] Update Tracker - [Reaction:170158] CDC25A dephosphorylates CCNA:CDK1 - v92:[modifyText]
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No pathways have been reviewed or authored by CDC25A dephosphorylates CCNA:CDK1 (170158)
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