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Details on Person WEE1 phosphorylates CCNA:CDK1

Class:IdReaction:170156
_displayNameWEE1 phosphorylates CCNA:CDK1
_doReleaseTRUE
_timestamp2025-01-22 15:39:59
catalystActivity[CatalystActivity:69254] protein tyrosine kinase activity of WEE1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:170148] Matthews, L, 2005-12-23 13:53:48
edited[InstanceEdit:9930140] Orlic-Milacic, Marija, 2024-12-03
figure[Figure:72793] /figures/cyclinab_cdk1_p.jpg
input[SimpleEntity:29358] ATP [nucleoplasm]
[CandidateSet:170092] CCNA:p-T14,T161-CDK1 [nucleoplasm] [Homo sapiens]
literatureReference[LiteratureReference:9929418] Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation
[LiteratureReference:9929422] PLK1 Activation in Late G2 Sets Up Commitment to Mitosis
modified[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9929423] Orlic-Milacic, Marija, 2024-11-25
[InstanceEdit:9929531] Orlic-Milacic, Marija, 2024-11-26
[InstanceEdit:9930140] Orlic-Milacic, Marija, 2024-12-03
[InstanceEdit:9932263] Orlic-Milacic, Marija, 2024-12-18
[InstanceEdit:9936326] Orlic-Milacic, Marija, 2025-01-22
nameWEE1 phosphorylates CCNA:CDK1
Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes
output[SimpleEntity:113582] ADP [nucleoplasm]
[CandidateSet:170147] CCNA:p-T14,Y15,T161-CDK1 [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2005-04-11
reviewed[InstanceEdit:9936318] Alwakeel, Alan, 2025-01-02
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359288] R-HSA-170156.4
summation[Summation:170203] WEE1-mediated tyrosine phosphorylation of CDK1 (Cdc2) bound ...
(hasEvent)[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(inferredFrom)[Reaction:1113068] Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes [Oryza sativa]
(orthologousEvent)[Reaction:1113068] Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes [Oryza sativa]
(precedingEvent)[Reaction:170158] CDC25A dephosphorylates CCNA:CDK1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9788835] Update Tracker - [Reaction:170156] Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes - v40:[modifyText]
[_UpdateTracker:9939670] Update Tracker - [Reaction:170156] WEE1 phosphorylates CCNA:CDK1 - v92:[modifyText, removeLiteratureReference]
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