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Details on Person Phosphorylation of Cyclin B1 in the CRS domain

Class:Id	Reaction:170126
_displayName	Phosphorylation of Cyclin B1 in the CRS domain
_doRelease	TRUE
_timestamp	2022-02-08 21:46:04
catalystActivity	[CatalystActivity:170129] protein serine/threonine kinase activity of CRS kinase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:170124] Matthews, L, 2005-12-23 13:40:29
input	[Complex:157456] CCNB1:p-T161-CDK1 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
literatureReference	[LiteratureReference:170205] Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal
modified	[InstanceEdit:170184] Matthews, L, 2005-12-28 10:02:46 [InstanceEdit:170596] Matthews, L, 2006-01-07 23:23:46 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9764023] Orlic-Milacic, Marija, 2022-02-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of Cyclin B1 in the CRS domain
output	[Complex:170121] Phospho-Cyclin B1 (CRS):phospho-Cdc2(Thr 161) [cytosol] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:170076] CAK phosphorylates CDK1 bound to CCNB1 [Homo sapiens] [Reaction:170044] Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus [Homo sapiens] [Reaction:170161] Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B [Homo sapiens] [Reaction:162657] Inactivation of Myt1 kinase [Homo sapiens] [Reaction:170120] Translocation of Cdc25B to the cytoplasm [Homo sapiens] [Reaction:170072] Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm [Homo sapiens] [BlackBoxEvent:4088305] FOXM1 stimulates PLK1 transcription [Homo sapiens] [Reaction:4088306] FOXM1 binds PLK1 promoter [Homo sapiens]
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358596] R-HSA-170126.4
summation	[Summation:170191] At the onset of mitosis, cyclin B is phosphorylated in the C...
(hasEvent)	[Pathway:69273] Cyclin A/B1/B2 associated events during G2/M transition [Homo sapiens]
(precedingEvent)	[Reaction:170131] Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes [Homo sapiens]
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